Disperse red 15 (DR15) impedes biofilm formation of uropathogenic Escherichia coli

Miryala, Sandeep; Makala, Himesh; Prasad, Yadavali Siva; Ulaganathan, Venkatasubramanian; Subbaiah, Nagarajan; Srinandan, C. S.

doi:10.1016/j.micpath.2019.103772

Cited by 11 publications

(5 citation statements)

References 43 publications

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“…The compound inhibited biofilm formation and adhesion in E. coli while it did not show any effect on the growth of planktonic cells. The compound inhibited autoaggregation and motility of the cells; swimming was observed to be inhibited at 10 μg/mL, while swarming was inhibited at 20 μg/mL concentration [128] …”

Section: Mechanisms Underlying Antibacterial Activitymentioning

confidence: 95%

“…Miryala et al [128] . tested the effect of 1‐amino‐4‐hydroxyanthraquinone 98 (disperse red 15) in preventing the formation of biofilms in uropathogenic Escherichia coli UTI89 (Figure 6).…”

Section: Mechanisms Underlying Antibacterial Activitymentioning

confidence: 99%

“…The compound inhibited autoaggregation and motility of the cells; swimming was observed to be inhibited at 10 μg/mL, while swarming was inhibited at 20 μg/mL concentration. [128]…”

Section: Synthetic Compounds Showing Antibiofilm Activitymentioning

confidence: 99%

“…Miryala et al [128] tested the effect of 1-amino-4-hydroxyanthraquinone 98 (disperse red 15) in preventing the formation of biofilms in uropathogenic Escherichia coli UTI89 (Figure 6). The compound inhibited biofilm formation and adhesion in E. coli while it did not show any effect on the growth of planktonic cells.…”

Section: Synthetic Compounds Showing Antibiofilm Activitymentioning

confidence: 99%

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Exploring Anthraquinones as Antibacterial and Antifungal agents

et al. 2023

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Anthraquinones having an anthracene core structure with two carbonyl groups are essential compounds in therapeutic applications. One of the growing concerns within the medical community is antimicrobial resistance. Multiple drug-resistant microbes can worsen a disease that can be easily treated with normal drugs. Microbes also produce biofilms that further enhance their resistance to antimicrobials, rendering biofilm-associated infections challenging to eradicate. This review provides an update on the antibacterial and antifungal activities of natural and synthetic anthraquinone derivatives. The mechanism of antibacterial and antifungal action of anthraquinones are summarised, which will help in designing new therapeutically effective anthraquinone compounds.

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Section: Mechanisms Underlying Antibacterial Activitymentioning

confidence: 95%

Section: Mechanisms Underlying Antibacterial Activitymentioning

confidence: 99%

“…The compound inhibited autoaggregation and motility of the cells; swimming was observed to be inhibited at 10 μg/mL, while swarming was inhibited at 20 μg/mL concentration. [128]…”

Section: Synthetic Compounds Showing Antibiofilm Activitymentioning

confidence: 99%

Section: Synthetic Compounds Showing Antibiofilm Activitymentioning

confidence: 99%

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Exploring Anthraquinones as Antibacterial and Antifungal agents

et al. 2023

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“…The disperse red 15 is a hydroxyl anthraquinone compound that can interfere with FimH, an adhesion factor at the end of the type I pili of E. coli . After the action of disperse red 15, swimming and swarming motilities were inhibited, and the initial adhesion was reduced, resulting in a reduction in biofilm biomass by more than 50% ( Miryala et al, 2020 ). This result indicated that disperse red 15 could better be used as surface coating to reduce bacterial adhesion and prevent biofilms formation.…”

Section: Reducing Reversible Adhesionmentioning

confidence: 99%

Strategies for Interfering With Bacterial Early Stage Biofilms

Zhang

Lin

et al. 2021

Front. Microbiol.

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Biofilm-related bacteria show high resistance to antimicrobial treatments, posing a remarkable challenge to human health. Given bacterial dormancy and high expression of efflux pumps, persistent infections caused by mature biofilms are not easy to treat, thereby driving researchers toward the discovery of many anti-biofilm molecules that can intervene in early stage biofilms formation to inhibit further development and maturity. Compared with mature biofilms, early stage biofilms have fragile structures, vigorous metabolisms, and early attached bacteria are higher susceptibility to antimicrobials. Thus, removing biofilms at the early stage has evident advantages. Many reviews on anti-biofilm compounds that prevent biofilms formation have already been done, but most of them are based on compound classifications to introduce anti-biofilm effects. This review discusses the inhibitory effects of anti-biofilm compounds on early stage biofilms formation from the perspective of the mechanisms of action, including hindering reversible adhesion, reducing extracellular polymeric substances production, interfering in the quorum sensing, and modifying cyclic di-GMP. This information can be exploited further to help researchers in designing new molecules with anti-biofilm activity.

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Novel Nano Drug‐Loaded Hydrogel Coatings for the Prevention and Treatment of CAUTI

Wu,

Yan,

et al. 2024

Adv Healthcare Materials

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Catheter‐associated urinary tract infection (CAUTI) is a prevalent type of hospital‐acquired infection, affecting approximately 15% to 25% of patients with urinary catheters. Long‐term use of the catheter can lead to colonization of microorganisms and biofilm formation, and may develop into bacterial CAUTI. However, the frequent replacement of catheters in clinical settings can result in tissue damage, inflammation, ulceration, and additional complications, causing discomfort and pain for patients. In light of these challenges, a novel nanodrug‐supported hydrogel coating called NP‐AM/FK@OMV‐P/H has been developed in this study. Through in vitro experiments, it is confirmed that OMV nano‐loaded liquid gel coating has an effective reaction against E.coli HAase and releases antibacterial drugs. This coating has also demonstrated strong inhibition of E.coli and has shown the ability to inhibit the formation of bacterial biofilm. These findings highlight the potential of the OMV nanoparticle gel coating in preventing and treating bacterial infections. Notably, NP‐AM/FK@OMV‐P/H has exhibited greater efficacy against multidrug‐resistant E.coli associated with UTIs compared to coatings containing single antimicrobial peptides or antibiotics. Additionally, it has demonstrated good biosecurity. In conclusion, the NP‐AM/FK@OMV‐P/H coating holds great potential in providing benefits to patients with CAUTI.

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Disperse red 15 (DR15) impedes biofilm formation of uropathogenic Escherichia coli

Cited by 11 publications

References 43 publications

Exploring Anthraquinones as Antibacterial and Antifungal agents

Exploring Anthraquinones as Antibacterial and Antifungal agents

Strategies for Interfering With Bacterial Early Stage Biofilms

Novel Nano Drug‐Loaded Hydrogel Coatings for the Prevention and Treatment of CAUTI

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