The influence of synthetic (Penostrom) and protein (Foam X) foaming agents on the physical and mechanical properties and microstructure of gypsum stone obtained by dry mineralization of low multiplicity foams (4-6) with high-strength separated gypsum was studied. When using foam based on the foaming agent Penostrom, the average density of gypsum stone is reduced to 430 kg/m 3 (by 3 times), the coefficient of thermal conductivity to 0.14 W/(mÁ°C ) (by 4 times), the compressive strength to 2.4 MPa (by 6 times). Foam based on foaming agent Foam X increases the compressive strength of gypsum stone to 17.5 MPa (by 1.2 times) with a slight increase in the average density (by 3%) and the coefficient of thermal conductivity (by 5%). It was found that the microstructure of gypsum stone with Penostrom is represented by largedispersed crystals of calcium sulfate dihydrate of plate-acicular morphology, meso pores (diameter 3.5-33 nm) with volume of 43•10 −3 cm 3 /g, macro pores (diameter 60-130 nm) with volume of 30•10 −3 cm 3 /g. The microstructure of gypsum stone with Foam X is characterized by the content of fine-dispersed, densely packed crystals CaSO 4 •2H 2 O of prismatic habitus, meso pores (diameter 3.5-33 nm) with volume of 57•10 −3 cm 3 /g, macro pores (diameter 60-130 nm) with volume of 19•10 −3 cm 3 /g.