The research has been done in the industrial region Devnya, Bulgaria for the term 2010 – 2014. The period has been chosen in accordance with the coming into force of the IPPC permits of the different operators of production installations. It has been used data from a monitoring station - automated measuring station "Izvorite" as the monthly and average annual concentrations of specific air pollutants were examined such as: SO2, NO2, O3, CO, C6H6, NH3 and PM10. The results show that the annual average concentrations of air pollutants are below the emission thresholds for the protection of human health. For some pollutants (PM10, SO2, NO2, CO and benzene) a seasonal dynamic was observed, associated mostly with emissions from combustion processes - heating in the residential and commercial sector. The results note also, that the measures, pursuant to the Integrated Pollution Prevention and Control permits (IPPC permits) of the industrial and combustion plants in the industrial region Devnya are effective and give their contribution for improvement of the ambient air quality.