Dispersion of amorphous silica nanoparticles via beads milling process and their particle size analysis, hydrophobicity and anti-bacterial activity

Joni, I Made; Muthukannan, Vanitha; Panatarani, Camellia; Faizal, Ferry

doi:10.1016/j.apt.2019.10.029

Cited by 21 publications

(6 citation statements)

References 44 publications

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“…This result indicated that the sample 3 was amorphous. The broadening of the peak for amorphous silica at 2θ = 23.5° was also reported by others [ 53 , 54 , 55 ]. The XRD pattern of sample 4 showed 30% of crystallinity.…”

Section: Resultssupporting

confidence: 85%

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

et al. 2020

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Prostate cancer is the second most frequent malignancy in men worldwide. Unfortunately, current therapies often lead to the onset of metastatic castration-resistant prostate cancer (mCRPC), causing significant mortality. Therefore, there is an urgent need for new and targeted therapies that are advantageous over the current ones. Recently, the PSMA-targeted radioligand therapy of mCRPC has shown very promising results. In line with this, we described the synthesis of a new radioimmunoconjugate, 223RaA-silane-PEG-D2B, for targeted mCRPC therapy. The new compound consists of a NaA zeolite nanocarrier loaded with the α-particle emitting Ra-223 radionuclide, functionalized with the anti-PSMA D2B antibody. Physicochemical properties of the synthesized compound were characterized by standard methods (HR-SEM, TEM, XRD, FTIR, EDS, NTA, DLS, BET, TGA). The targeting selectivity, the extent of internalization, and cytotoxicity were determined in LNCaP C4-2 (PSMA+) and DU-145 (PSMA-) cells. Our results supported the 223RaA-silane-PEG-D2B synthesis and revealed that the final product had a diameter ca. 120 nm and specific activity 0.65 MBq/1mg. The product was characterized by a high yield of stability (>95% up to 12 days). The conjugation reaction resulted in approximately 50 antibodies/nanoparticle. The obtained radioimmunoconjugate bound specifically and internalized into PSMA-expressing LNCaP C4-2 cells, but not into PSMA-negative DU-145 cells. 223RaA-silane-PEG-D2B demonstrated also potent cytotoxicity in LNCaP C4-2 cells. These promising results require further in vivo evaluation of 223RaA-silane-PEG-D2B with regard to its toxicity and therapeutic efficacy.

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Section: Resultssupporting

confidence: 85%

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

et al. 2020

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“…It has been reported that adhesion proteins present on the surface of bacteria are rich in hydrophobic domains, which make them easy to adhere to hydrophobic interfaces, thereby causing infection. , According to the hydrophobic characteristics of the bacterial surface, hydrophobic antibacterial agents are expected to target bacteria through hydrophobic interaction to achieve high-efficiency antibacterial effects. , For instance, Yang and his team prepared a thermosensitive gel layer (TRGL)-containing, MOF-derived nanocarbon-based ZnO-CNP-TRGL composite that offers hydrophobic interaction to target bacteria and exhibits NIR-responsive photothermal activity and Zn 2+ releasing activity . The TRGL possessed high hydrophilicity at room temperature, which makes the ZnO-CNP-TRGL well dispersed and thus having low bacterial interaction ability.…”

Section: Bacterial-targeted Precise Antibacterial Strategiesmentioning

confidence: 99%

“…Thus, bacterial infection of wounds should be detected and treated as soon as possible. In recent years, many SAMN-based antibacterial strategies have been demonstrated for surgical wound treatment. ,,,, …”

Section: Emerging Applications Of Samnsmentioning

confidence: 99%

“…Common wound infections can occur in burn wounds, combat-related wounds, surgical wounds, or chronic wounds like diabetic ulcers . With the aggravation of infection, pus may appear at the wound site and may eventually lead to nonhealing of the wound, which not only affects the patient’s normal life but also creates substantial financial burden .…”

Section: Emerging Applications Of Samnsmentioning

confidence: 99%

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Stimuli-Activable Metal-Bearing Nanomaterials and Precise On-Demand Antibacterial Strategies

et al. 2022

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Bacterial infections remain the leading cause of death worldwide today. The emergence of antibiotic resistance has urged the development of alternative antibacterial technologies to complement or replace traditional antibiotic treatments. In this regard, metal nanomaterials have attracted great attention for their controllable antibacterial functions that are less prone to resistance. This review discusses a particular family of stimuli-activable metal-bearing nanomaterials (denoted as SAMNs) and the associated on-demand antibacterial strategies. The various SAMN-enabled antibacterial strategies stem from basic light and magnet activation, with the addition of bacterial microenvironment responsiveness and/or bacteriatargeting selectivity and therefore offer higher spatiotemporal controllability. The discussion focuses on nanomaterial design principles, antibacterial mechanisms, and antibacterial performance, as well as emerging applications that desire on-demand and selective activation (i.e., medical antibacterial treatments, surface anti-biofilm, water disinfection, and wearable antibacterial materials). The review concludes with the authors' perspectives on the challenges and future directions for developing industrial translatable next-generation antibacterial strategies.

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“…In addition, the XRD pattern of the synthesized SiO 2 nanoparticles is presented in Figure S2A in Supplementary Materials. Briefly, the XRD pattern reveals a broad peak related to amorphous silica nanoparticles, at 2θ = 23 • , with (101) Miller indices [30]. γ (g/cm 3 ); γ s (g/cm 3 ) and the Total Porosity decomposition (%) measurements exhibit an experimental error of 0.01.…”

Section: Samples Collectionmentioning

confidence: 99%

SiO2 Nanoparticles as New Repairing Treatments toward the Pietraforte Sandstone in Florence Renaissance Buildings

Valentini

Pallecchi²,

Relucenti

et al. 2022

Crystals

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In this work, the consolidation efficiency of SiO2 nanoparticles (synthesized in the Chemistry laboratories at the Tor Vergata University of Roma) was tested on Pietraforte sandstone surfaces belonging to the bell tower of San Lorenzo (Florence, Italy) and was fully investigated. Nanoparticles (synthesized in large-scale mass production) have been characterized by XRD—X-Ray Diffraction; Raman and FTIR—Fourier Transform Infrared spectroscopy; SEM—Scanning Electron Microscopy; while the Pietraforte sandstone morphology was examined by Porosimetry, capillary absorption test, surface hardness test, drilling resistance and tensile strength. The colorimetric measurements were also performed to characterize the optical modification exhibited by Pietraforte sandstones, especially after the SiO2 treatments. Our results show that applying to the Pietraforte, the new consolidating agent based on SiO2 nanoparticles, has several advantages, as they are more resistant to perforation, wear, and abrasion even long range (for long times of exposure and consolidating exercise against Florentine sandstone), compared to the CaCO3 nanoparticles (tested in our previous paper), which instead show excellent performance but only close to their first application. This means that over time, their resistance to drilling decreases, they wear much more easily (compared to SiO2-treated sandstone), and tend to exhibit quite a significant surface abrasion phenomena. The experimental results highlight that the SiO2 consolidation efficiency on this kind of Florentine Pietraforte sandstone (having low porosity and a specific calcitic texture) seems to be higher in terms of water penetration protection, superficial cohesion forces, and an increase in surface resistance. Comparing the performance of SiO2 nanoparticles with commercial consolidants in solvents such as Estel 1000 (tested here), we demonstrate that: (A) the restorative effects are obtained with a consolidation time over one week, significantly shorter when compared to the times of Estel 1000, exceeding 21 days; (B) SiO2 nanoparticles perform better than Estel 1000 in terms of cohesion forces, also ensuring excellent preservation of the optical and color properties of the parent rock (without altering it after application).

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Dispersion of amorphous silica nanoparticles via beads milling process and their particle size analysis, hydrophobicity and anti-bacterial activity

Cited by 21 publications

References 44 publications

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

Stimuli-Activable Metal-Bearing Nanomaterials and Precise On-Demand Antibacterial Strategies

SiO2 Nanoparticles as New Repairing Treatments toward the Pietraforte Sandstone in Florence Renaissance Buildings

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