Dispersion of the Corrected QT and JT Interval in the Electrocardiogram of Alcoholic Patients

Čorović, Naima; Duraković, Zijad; Mišıgoj-Duraković, Marjeta

doi:10.1111/j.1530-0277.2006.00018.x

Cited by 18 publications

(14 citation statements)

References 22 publications

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“…People who consume an excessive amount of alcoholic beverages for a long time have significantly higher dispersions of the QTc and JTc intervals and have a significantly higher estimation of relative risk for prolonged QTc interval and higher QTc dispersion than control subjects, i.e. higher risk of arrhythmias …”

Section: Diagnosismentioning

confidence: 87%

“…higher risk of arrhythmias. 131 Chronic ethanol consumption has been shown to cause a significant deterioration in left ventricular diastolic function, irrespective of its effect on blood pressure and left ventricular mass. 109 Systolic left ventricular dysfunction is relatively common even in asymptomatic alcoholics, but whether diastolic function is also altered is much less well studied.…”

Section: Diagnosismentioning

confidence: 99%

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Alcohol abuse and heart failure

Laonigro

Correale

Biase

et al. 2009

European J of Heart Fail

164

109

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Alcoholic patients who consume .90 g of alcohol a day for .5 years are at risk of developing asymptomatic alcoholic cardiomyopathy (ACM). Those patients who continue to drink may become symptomatic and develop signs and symptoms of heart failure (HF). This distinct form of congestive HF is responsible for 21-36% of all cases of non-ischaemic dilated cardiomyopathy in Western Society. Without complete abstinence, the 4 year mortality for ACM is close to 50%. This short review summarizes the experimental and clinical evidence regarding the role of alcohol in the pathophysiology of ACM and HF.--

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Section: Diagnosismentioning

confidence: 87%

Section: Diagnosismentioning

confidence: 99%

Alcohol abuse and heart failure

Laonigro

Correale

Biase

et al. 2009

European J of Heart Fail

164

109

View full text Add to dashboard Cite

show abstract

“…Mainly chronic alcoholics and individuals with coexisting heart diseases causing structural and functional myocardial changes are predisposed to arrhythmias (for a review, see [8,35,38]. The potential arrhythmogenic effect of alcohol may be further increased particularly under an increased sympathetic tone, usage of drugs, ionic imbalance or polymorphisms/mutations in genes encoding ionic channels [16,31,33,43,48].…”

Section: Discussionmentioning

confidence: 98%

“…8,8, and 50 mM (~0.04, 0.4, and 2.3 ‰, respectively[3]). The application of ethanol at a very low concentration (0.8 mM) caused APD prolongation, while higher concentrations (8 and 50 mM) caused APD shortening(Fig.…”

mentioning

confidence: 99%

Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study

Pásek

Bébarová

Christé

et al. 2015

Med Biol Eng Comput

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Alcohol consumption may result in electrocardiographic changes and arrhythmias, at least partly due to effects of ethanol on cardiac ionic currents. Contractility and intracellular Ca(2+) dynamics seem to be altered as well. In this study, we integrated the available (mostly animal) experimental data into previously published models of the rat and human ventricular myocytes to assess the share of ionic current components in ethanol-induced changes in AP configuration and cytosolic Ca(2+) transient in ventricular cardiomyocytes. The rat model reproduced well the experimentally observed changes in AP duration (APD) under ethanol (slight prolongation at 0.8 mM and shortening at ≥8 mM). These changes were almost exclusively caused by the ethanol-induced alterations of I K1. The cytosolic Ca(2+) transient decreased gradually with the increasing ethanol concentration as a result of the ethanol-induced inhibition of I Ca. In the human model, ethanol produced a dose-dependent APD lengthening, dominated by ethanol effect on I Kr, the key repolarising current in human ventricles. This effect might contribute to the clinically observed proarrhythmic effects of ethanol in predisposed individuals.

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“…9,11,14,15,17 The QT represents the ventricular cell transmembrane action potential, the electric systole of the ventricles, i.e. the time from the beginning of ventricular depolarization to its completion (a delay between depolarization time and the end of repolarization).…”

Section: Discussionmentioning

confidence: 99%

Heart Rate–Corrected QT and JT Intervals in Electrocardiograms in Physically Fit Students and Student Athletes

Mišıgoj-Duraković

Duraković²,

Prskalo³

2016

Noninvasive Electrocardiol

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In literature, data on the prevalence of prolonged and shortened corrected QT (QTc) have shown considerable variability. The aim of the study was to compare QTc and JTc intervals of competitive student athletes and noncompetitive sport participants to QTc cutoff points used in athletes. A group of 485 physically fit candidates for the study of kinesiology (139 female and 346 male candidates) aged 18-20 participated in the study. Basic anthropometry, field fitness test, cardiovascular, electrocardiograms measurements, and blood sampling for lipid profile were conducted. The prolonged QTc according to European Society of Cardiology criteria was found in 2.9% of female and 4.3% of male students. When the "Seattle criteria" were used, the proportion of prolonged QTc was 1.44% in female and 0.29% in male students. The shortened QTc according to the Seattle cutoff points was presented in 0.7% of female and 2.0% of male students. The JTc over 400 ms was found in 0.72% of female and 0.29% of male students. The JTc shorter than 320 ms was presented in 0.7% of female and 1.1% of male students. No significant differences were found between students involved in competitive sport and those involved in recreational sporting activities. Female students had lower body mass index and blood pressure values, better blood lipid profile, and lower uric acid concentrations. In conclusion, the Seattle criteria markedly decreased the proportion of prolonged QTc in student athletes, particularly in male students. It seems that the JTc interval could be a better parameter than the QTc interval for the estimation of specific repolarization time in physically fit university students.

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Dispersion of the Corrected QT and JT Interval in the Electrocardiogram of Alcoholic Patients

Cited by 18 publications

References 22 publications

Alcohol abuse and heart failure

Alcohol abuse and heart failure

Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study

Heart Rate–Corrected QT and JT Intervals in Electrocardiograms in Physically Fit Students and Student Athletes

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