Dispersive liquid-liquid microextraction followed by gas chromatography–mass spectrometry for the determination of pesticide residues in nutraceutical drops

Szarka, Agneša; Turková, Dominika; Hrouzková, Svetlana

doi:10.1016/j.chroma.2018.07.072

Cited by 36 publications

(18 citation statements)

References 33 publications

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“…A number of water-immiscible organic solvents with different densities than water and good abilities for analyte solvation were tested to achieve the best extraction [30]. The solvents were added to 14 mL of the derivatization reaction mixture from 0.2 mM eugenol.…”

Section: Optimization Of Dllme Methodsmentioning

confidence: 99%

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Determination of Eugenol in Personal-Care Products by Dispersive Liquid-Liquid Microextraction Followed by Spectrophotometry Using p-Amino-N,N-dimethylaniline as a Derivatizing Agent

et al. 2020

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Two simple methods for the determination of eugenol were developed. The first depends on the oxidative coupling of eugenol with p-amino-N,N-dimethylaniline (PADA) in the presence of K3[Fe(CN)6]. A linear regression calibration plot for eugenol was constructed at 600 nm, within a concentration range of 0.25-2.50 μg.mL–1 and a correlation coefficient (r) value of 0.9988. The limits of detection (LOD) and quantitation (LOQ) were 0.086 and 0.284 μg.mL–1, respectively. The second method is based on the dispersive liquid-liquid microextraction of the derivatized oxidative coupling product of eugenol with PADA. Under the optimized extraction procedure, the extracted colored product was determined spectrophotometrically at 618 nm. A linear plot within a concentration range of 0.05–1.65 μg.mL–1 (r = 0.9997) was constructed. The LOD and LOQ were 0.053 and 0.177 μg.mL–1, respectively. Both methods were tested for the analysis of eugenol in commercial personal-care products, and the results confirmed that the procedures are accurate, precise, and reproducible (RSD < 1%).

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Section: Optimization Of Dllme Methodsmentioning

confidence: 99%

“…Generally, the ionic strength or salt effect tends to decrease the solubility of analytes in the aqueous phase and tends to increase the water immiscibility of organic solvent [30]. Therefore, the ionic strength of the aqueous phase was adjusted to increase the extraction yield.…”

Section: Optimization Of Dllme Methodsmentioning

confidence: 99%

Determination of Eugenol in Personal-Care Products by Dispersive Liquid-Liquid Microextraction Followed by Spectrophotometry Using p-Amino-N,N-dimethylaniline as a Derivatizing Agent

et al. 2020

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“…To assess the capability of the proposed method to extract and determine the OPPs in real matrices, the water and juice samples were analyzed by the optimized analytical procedure. Matrix effect can be used to compare the response of the detector signal for the analytes in real and solvent sample solutions (26). At first, the matrix-matched calibration curves were obtained in order to attain accurate results and determining the extent of matrix effects.…”

Section: Real Samples Analysismentioning

confidence: 99%

“…The mixture is entered into an aqueous sample solution by rapid injection, forming a cloudy phase with fine droplets of the extractant (18,19). DLLME technique has been operated via different strategies for extraction of OPPs from real matrices (4,18,(20)(21)(22)(23)(24)(25)(26). In all of these procedures, a disperser solvent (0.5 -1.5 mL) has been used to disperse an organic extraction solvent in the whole sample solution, which accelerates the extraction of analytes.…”

Section: Introductionmentioning

confidence: 99%

Ultra Rapid and Highly Sensitive Disperser-less Liquid-liquid Microextraction of Organophosphate Pesticides Prior to Gas Chromatography with Mass Spectrometry Detection

Rahbar

Hesami

Ramezani

et al. 2020

Jundishapur J Health Sci

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Background: Organophosphates (OPPs) are toxic chemicals that can cause serious health problems through poisoning water and food. Objectives: A very simple and fast disperser-less liquid microextraction strategy before chromatographic detection was designed for the analysis of organophosphates in various water solutions. Methods: A 60 µL aliquot of chloroform, as extraction solvent (without using disperser), was introduced into the sample solution by rapid injection, and the sedimented organic phase was analyzed to assay some organophosphates. Results: Analytical characteristics, including limits of detection (0.0003 - 0.001 µg.L-1), linear dynamic ranges (0.001 - 100 µg.L-1), relative standard deviations (2.5 - 10), enrichment factors (up to 238), and extraction recoveries (84% - 108%), indicated the high efficacy of the developed method for analyzing the target analytes. Conclusions: The proposed procedure was effectively used for the analysis of the OPPs in real tap water, river water, and fruit juice samples. In the present study, the examined analytes were in the range of 0.07 - 1.56 µg.L-1.

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“…The extraction solvent is finely dispersed in the sample solution with the aid of dispersive solvent and the analytes are transferred into the droplets efficiently. [22][23][24] Different liquids including organic solvents heavier or lighter than water, 25 room temperature ionic liquids (RTILs), 26 supramolecules, 27 and deep eutectic solvents (DESs) 28 were used as the possible extraction solvent in DLLME. Toxicity and availability of the solvent is important factor in its utilization as extraction solvent in DLLME and the use of green solvents as a substitute of organic solvents is preferred.…”

Section: Introductionmentioning

confidence: 99%

Development of Salt Induced Liquid–Liquid Extraction Combined with Amine Based Deep Eutectic Solvent-Dispersive Liquid–Liquid Microextraction; An Efficient Analytical Method for Determination of Three Anti-Seizures in Urine Samples

et al. 2020

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Background: A simple, fast, efficient, and environmentally friendly microextraction technique named salt induced liquid-liquid extraction combined with amine based deep eutectic solventdispersive liquid-liquid microextraction method followed by gas chromatography-flame ionization detector was applied for the determination of some anti-seizure drugs in urine samples. Methods: In this method, sodium chloride (30% w/v) was dissolved in the sample solution (adjusted at pH=10) as phase separation agent and iso-propanol was added to the solution. After manually shaking, the solution was centrifuged and the supernatant phase was removed and mixed with choline chloride: benzyl ethylenediamine (85 µL) and the mixture was rapidly dispersed into a deionized water containing 5.0 % w/v, sodium chloride and adjusted at pH=10. The cloudy solution was centrifuged and the sedimented phase was removed and 1 µL of it was injected into the determination system. Results: Under final conditions, the limits of detection and quantification at the ranges of 3.4-6.9, and 11.5-23.3 ng mL -1 were obtained, respectively. The relative standard deviations for intraand inter day assays were lower than 10.9%. The effect of exogenous and endogenous effect on the performance of the method was studied and the results showed that these factors were nearly effect less on the efficiency. Conclusion:The introduced method was satisfactorily utilized to determinate the selected benzodiazepines drugs in the patients' urine samples.

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Dispersive liquid-liquid microextraction followed by gas chromatography–mass spectrometry for the determination of pesticide residues in nutraceutical drops

Cited by 36 publications

References 33 publications

Determination of Eugenol in Personal-Care Products by Dispersive Liquid-Liquid Microextraction Followed by Spectrophotometry Using <i>p</i>-Amino-<i>N,N</i>-dimethylaniline as a Derivatizing Agent

Determination of Eugenol in Personal-Care Products by Dispersive Liquid-Liquid Microextraction Followed by Spectrophotometry Using <i>p</i>-Amino-<i>N,N</i>-dimethylaniline as a Derivatizing Agent

Ultra Rapid and Highly Sensitive Disperser-less Liquid-liquid Microextraction of Organophosphate Pesticides Prior to Gas Chromatography with Mass Spectrometry Detection

Development of Salt Induced Liquid–Liquid Extraction Combined with Amine Based Deep Eutectic Solvent-Dispersive Liquid–Liquid Microextraction; An Efficient Analytical Method for Determination of Three Anti-Seizures in Urine Samples

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