The use of digitization and virtual, multisensory presentation techniques in the study of natural and environmental processes, industry, technology, history, medicine, etc., the basis of which is scientific data, complements development and research areas, accelerates and facilitates computer-assisted insight and interpretation of results. By dealing with digital information, we not only deepen the research process, but also expand the possibilities of information presentation outside scientific research circles, in society, thus bringing basic knowledge closer to different target groups through interpretive approaches of human-oriented design. Multimedia, interactive, multisensory media, and extended realities are a bridge between the scientific result and the user experience. These media raise awareness and teach people to live with the nature, in the environment, to use the scientific context through the creative design and delivery of digital content. This paper presents some starting points and guidelines of preparing graphic content in a way that holistically and multisensory engages the participants of the experience. At the end some examples of the application of graphical multisensory presentations are shown: documentation, popularization of science at micro and macro levels, analysis and measurement, simulation and training, animation and interactivity, 3D modelling and reconstruction, stylisation and interpretation, argumentation of physical realities and extension into the new reality.