Disposable Flat Panel Airlift Photobioreactors

Bergmann, Peter G.; Ripplinger, Peter; Beyer, Lars; Trösch, Walter

doi:10.1002/cite.201200132

Cited by 35 publications

(12 citation statements)

References 24 publications

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“…Bergmann et al suggested changing the material of the flat panel airlift photobioreactor developed by Subitec (Stuttgart, Germany) from PVC to other single-use materials when it is to be utilized as a single-use technology. Cultivations with Phaeodactylum tricornutum (Bacillariophyceae, eicosapentaenoic acid), Haematococcus pluvialis (Chlorophyceae, astaxanthin), and Nannochloropsis oculata (Eustigmatophyceae, polyunsaturated fatty acids) have been performed successfully in flat panel reactors specifically designed for cultivation of phototrophic microalgae [43]. Lehman et al applied the wave-mixed BIOSTAT CultiBag RM (Satorius Stedim Biotech) equipped with red and white LEDs, the wave-mixed AppliFlex (Applikon Biotechnology) with white light LEDs, and the orbital shaken CultiBag RM operated in the Multitron Cell shaker (Infors HT) and equipped with cool white fluorescent tubes.…”

Section: Cultivation Of Phototrophic Microalgae In Single-use Bioreacmentioning

confidence: 99%

Cultivation of Marine Microorganisms in Single-Use Systems

Hillig

Pilarek

Junne

et al. 2013

Advances in Biochemical Engineering/Biotechnology

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: Marine cultures are an important source of novel substances and enzymes. As efforts to isolate strains from (deep) sea environments increase, the demand for methodology platforms to cultivate these organisms is also rising. Due to the high salt concentration and the shear sensitivity exhibited by some heterotrophic microalgae, single-use systems originally designed for the cultivation of mammalian cell lines can be a valuable alternative. Using the cultivation of the heterotrophic marine microalgae Crypthecodinium cohnii as an example, this chapter makes suggestions for experimental design, for improving process development by integrating parallel experiments, and for scaling-up and scaling-down methodologies. It describes how to identify suitable single-use systems and how to integrate a two-layer system with perfluordecalin to improve the gas transfer in deep-well plates. The process is also scaled up in several single-use systems. We also describe challenges in the process development to achieve sufficient oxygen transfer, monitoring, and control, and we discuss limitations such as corrosion, long-term stability, and leachables in single-use systems. Finally, we demonstrate a method for cheap, fast, and consistent process development for marine microorganisms.

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Section: Cultivation Of Phototrophic Microalgae In Single-use Bioreacmentioning

confidence: 99%

Cultivation of Marine Microorganisms in Single-Use Systems

Hillig

Pilarek

Junne

et al. 2013

Advances in Biochemical Engineering/Biotechnology

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“…FP PBRs are made of parallel flat transparent panels (Figure ), 0.1‐0.15 m apart, which are organized to form a rectangular channel . They possess a very short light path that allows photons to easily penetrate the culture medium.…”

Section: Different Types Of Algal Pbrsmentioning

confidence: 99%

Biophotonics for improving algal photobioreactor performance: A review

et al. 2020

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The use of algae as a feedstock for biofuels production has drawn considerable attention due to their high biomass yield, their ability to be cultivated using degraded water on nonarable land, and their ability to recover nutrients from wastewater. Although algae have the potential to provide biomass for biofuels, some challenges remain and the limitations may be overcome by improving algal growth rates together with lipid synthesis. To achieve this, scientific researchers have focused on isolating and screening algal strains with better growth rates and lipid synthesis capabilities, bioengineering, and optimizing culture systems. The present review focuses on the biophotonic-based manipulations that can be applied to optimize solar-powered photobioreactors (PBRs).Hence, three different types of solar filters are reviewed herein, that is, the colored glass, thin-film, and thermochromic filters. This review provides evidence that bright red-colored glass filters can lower the spectral intensity of solar radiation from 1982.13 to 393.71 μmol m −2 s −1 , which is preferable for improved biomass productivity. Changing filter color, once the desired biomass concentration has been amassed, to medium blue or bright pink further improves lipid yield. A 34% improvement in biomass productivity was observed for Chlorella vulgaris cultured under thin-film filters. Thin-film filters are also effective in regulating PBR temperature within the 24-31 C range, which is tolerable for most algal species. Furthermore, this study highlights that the applicability of thermochromic filters in PBR designs is still yet to be investigated. Thermochromic filters are reflective and absorptive under high and low temperatures, respectively, a technology that can be a solution to the overheating challenge of PBRs. This review recommends the coupling of these light

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“…Eines der großen Themengebiete des aktuellen Jahrzehnts ist die Entwicklung neuartiger Einwegbioreaktoren (englisch: Single‐use bioreactor oder disposable bioreactor ). Zwar werden bereits seit einigen Dekaden Einwegbiorektoren genutzt , aber aufgrund gestiegener Ansprüche an Flexibilität, Benutzerfreundlichkeit und den direkten Einsatz ohne Vorbereitung ist das Thema aktueller denn je . Daher widmet sich auch die CIT im Februar 2013 in einem Sonderheft mit dem Titel Single‐Use Technology diesem Thema.…”

Section: Biotechnologie 1949 Bis Heuteunclassified

“…In dem Sonderheft sind Beiträge zu verschiedensten Themen im Zusammenhang mit Einwegbioreaktoren zu finden – ein klarer Fokus liegt aber auf den Beutelreaktoren. Kaiser et al befassen sich in gleich vier Publikationen mit ringförmigen, orbital geschüttelten Beutelreaktoren . Die besondere Bedeutung dieser Beutelreaktoren ist auf die gesteigerte Relevanz der Kultivierung scherempfindlicher Gewebezellen zu Zwecken der roten Biotechnologie zurückzuführen .…”

Section: Biotechnologie 1949 Bis Heuteunclassified

90 Years CIT – 90 Years Development in Biotechnology and Bioprocess Engineering

Akermann

Bold

Mehring

et al. 2018

Chemie Ingenieur Technik

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90 Jahre Chemie Ingenieur Technik (CIT) spiegeln wesentliche Meilensteine der Entwicklung der Biotechnologie und Bioprozesstechnik wider. In diesem Artikel werden einige der wichtigsten Entwicklungen vorgestellt und die Ausbildung von Trends in der Bioverfahrenstechnik nachgezeichnet. Beim Lesen der älteren Artikel lässt sich feststellen, dass einige der aktuellen Forschungsgebiete durchaus nicht ganz so neu sind, sondern vielversprechende Ansätze auch früher schon bearbeitet wurden.

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Disposable Flat Panel Airlift Photobioreactors

Cited by 35 publications

References 24 publications

Cultivation of Marine Microorganisms in Single-Use Systems

Cultivation of Marine Microorganisms in Single-Use Systems

Biophotonics for improving algal photobioreactor performance: A review

90 Years CIT – 90 Years Development in Biotechnology and Bioprocess Engineering

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