Disposable microfluidic substrates: Transitioning from the research laboratory into the clinic

Kuo, Jason S.; Chiu, Daniel T.

doi:10.1039/c1lc20125e

Cited by 71 publications

(57 citation statements)

References 150 publications

(152 reference statements)

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“…On the other extreme, techniques using paper and polyester-toner have been used to manufacture chips in less than 10 min with a cost lower than $ 0.10 per device, but the chemistry and topography of the materials often hinder the applicability of the technology [10,14,15]. Besides these examples, a range of polymers have emerged as alternative materials to fabricate ME devices [16][17][18][19]. In most cases, these plastics offer an adequate balance between fabrication procedures, cost, and analytical performance.…”

Section: Introductionmentioning

confidence: 99%

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Gabriel,

Coltro,

Garcia

2014

Electrophoresis

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This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster and vector while the explored engraving parameters included power, speed, frequency, resolution, line-width and number of passes. Under the optimum conditions, the technique was applied to produce channels suitable for CE separations. Taking advantage of the possibility to cut-through the substrates, the laser was also used to define solution reservoirs (buffer, sample, and waste) and a PDMS-based decoupler. The final device was used to perform the analysis of a model mixture of phenolic compounds within 200 s with baseline resolution.

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Section: Introductionmentioning

confidence: 99%

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Gabriel,

Coltro,

Garcia

2014

Electrophoresis

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“…Finally, it should be noted that the use of regulatory-approved materials or modified regulatory-approved materials does not mean the device is regulatoryapproved, but that it may encounter less regulatory resistance. 8 …”

Section: A Cytotoxicitymentioning

confidence: 99%

“…9 Additionally, devices manufactured with regulatoryapproved materials may be more rapidly approved for use. 8 The commercial development of clinical microfluidic devices requires low-cost materials from regulatory-approved suppliers.…”

Section: Introductionmentioning

confidence: 99%

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Manufacturing and wetting low-cost microfluidic cell separation devices

et al. 2013

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Deterministic lateral displacement (DLD) is a microfluidic size-based particle separation or filter technology with applications in cell separation and enrichment. Currently, there are no cost-effective manufacturing methods for this promising microfluidic technology. In this fabrication paper, however, we develop a simple, yet robust protocol for thermoplastic DLD devices using regulatory-approved materials and biocompatible methods. The final standalone device allowed for volumetric flow rates of 660 ll min À1 while reducing the manufacturing time to <1 h. Optical profilometry and image analysis were employed to assess manufacturing accuracy and precision; the average replicated post height was 0.48% less than the average post height on the master mold and the average replicated array pitch was 1.1% less than the original design with replicated posts heights of 62.1 6 5.1 lm (mean 6 6 standard deviations) and replicated array pitches of 35.6 6 0.31 lm.

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“…On the other hand, the disposability of clinical diagnostic devices necessitates the use of plastics as the main substrate material to satisfy the practical requirements of a low production cost and mass producibility [6]. Therefore, several groups have explored a hybrid device approach, where soft materials such as elastomers are implemented into rigid plastic materials to fabricate microvalves or micropumps.…”

Section: Introductionmentioning

confidence: 99%

Integration of Heteromaterial Microelements into Plastic Microfluidic Devices by Capillary-force-assisted Micromolding

Terane

Kobayashi

Ichikı

2014

J. Photopol. Sci. Technol.

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We propose an advanced micromolding process for integrating heteromaterial microelements with complicated structures into a plastic substrate. The technique comprises the autonomous filling of dispensed liquid prepolymers into microstructures pre-engraved on a plastic substrate and subsequent curing to induce the cross-linking of the prepolymers. Specifically, the fabrication of a self-standing poly(dimethylsiloxane) elastomer membrane into a rigid plastic substrate has been investigated. Based on the experimental results, a guiding principle for the dimension control of the finally formed structure is discussed by considering the balance between the capillary force and gravity acting on the liquid prepolymer. Moreover, the present technique has been preliminarily applied to a lab-on-a-chip technology: the implementation of elastomer-based pneumatic microvalves on plastic-based microfluidic devices.

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Disposable microfluidic substrates: Transitioning from the research laboratory into the clinic

Cited by 71 publications

References 150 publications

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Manufacturing and wetting low-cost microfluidic cell separation devices

Integration of Heteromaterial Microelements into Plastic Microfluidic Devices by Capillary-force-assisted Micromolding

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