Disposable roll-to-roll hot embossed electrophoresis chip for detection of antibiotic resistance genemecA in bacteria

Liedert, Ralph; Amundsen, Lotta K.; Hokkanen, Ari; Mäki, Minna; Aittakorpi, Anne; Pakanen, Mikko; Scherer, James R.; Mathies, Richard A.; Kurkinen, Marika; Uusitalo, Sanna; Hakalahti, Leena; Nevanen, Tarja K.; Siitari, Harri; Söderlund, Hans

doi:10.1039/c1lc20782b

Cited by 53 publications

(48 citation statements)

References 39 publications

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“…The reduced size of these devices makes them amicable to fabrication by large-scale manufacturing methods such as roll-to-roll processing. 31 Indeed, we have successfully fabricated these devices in PET and PMMA in collaboration with VTT Technical Research Centre of Finland using this approach. Ultimately, this could lead to inexpensive, disposable devices.…”

Section: Design Optimizationmentioning

confidence: 99%

Continuous separation of blood cells in spiral microfluidic devices

2013

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Blood cell sorting is critical to sample preparation for both clinical diagnosis and therapeutic research. The spiral inertial microfluidic devices can achieve label-free, continuous separation of cell mixtures with high throughput and efficiency. The devices utilize hydrodynamic forces acting on cells within laminar flow, coupled with rotational Dean drag due to curvilinear microchannel geometry. Here, we report on optimized Archimedean spiral devices to achieve cell separation in less than 8 cm of downstream focusing length. These improved devices are small in size (<1 in. 2 ), exhibit high separation efficiency ($95%), and high throughput with rates up to 1 Â 10 6 cells per minute. These device concepts offer a path towards possible development of a lab-on-chip for point-of-care blood analysis with high efficiency, low cost, and reduced analysis time. V C 2013 AIP Publishing LLC.

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Section: Design Optimizationmentioning

confidence: 99%

Continuous separation of blood cells in spiral microfluidic devices

2013

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“…nanoimprinting at such a high throughput and low cost that they can be used only once and disposed off or recycled economically. This technique results in the production of textured films by employing a mold mounted, etched, or directly written onto a roller, which is in contact with the imprint medium to pattern the film surface [140,145]. The SEM cross-sectional view of the resin mold manufactured by UV roll-to-roll nanoimprinting indicates a nanostructure with a 50 nm feature diameter, up to 120 cm 2 area, and a 10 m/min throughput.…”

Section: Nanoreplicationmentioning

confidence: 99%

Nanomanufacturing—Perspective and applications

et al. 2017

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“…Compared to 3D printing techniques, roll-to-roll printing has been dominant for large area fabrication. [74][75][76][77][78] In this part, we review existing techniques and provide guidance for future RTR technologies.…”

Section: Roll-to-roll Printing (Rtr)mentioning

confidence: 99%

Advances in 2D/3D Printing of Functional Nanomaterials and Their Applications

Choi

Das

Theodore³

et al. 2015

ECS J. Solid State Sci. Technol.

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Advanced printing techniques include innovative and/or integrated processes that are used to produce an object with enhanced functionality and with a wide range of applications. This is done by realizing printing of functional materials such as ink, paste, polymer, ceramic powder, and organic materials. Unlike conventional manufacturing methods, a new technique is needed to manipulate small objects to fabricate desired parts, as materials are scaled down to the nanometer range. In this regard, the traditional subtractive production has been changed to a bottom-up approach as device structures have changed to multilayer structures which contain several functional nanomaterials. A powder is used to fabricate an object with a desired geometry. This reduces the material loss due to the bottom-up nature of the process. In this article, we review the current state of knowledge for advanced manufacturing using two methods, 3D printing and roll-to-roll manufacturing. 3D printers developed in the early 1980s1 has created a revolution in research and development and teaching laboratories due to a substantial price drop after 2010 and an easy software called plugplay that allows most people to use it without extensive technical help.2,3 Based on economic analysis, the market for 3D printers is growing significantly. This is driven by a number of sectors including aerospace, automotive, and medical/dental and the market was worth several billions in 2013. During the last decade, the business has increased exponentially due to the 3D printing technology enabling the fabrication of complex objects with enhanced functionalities and improved material properties.4,5 Desktop 3D printers were targeted primarily at hobbyists and consumers who are not in industry. However, the need of industry-level 3D printers has attracted a lot of attention from researchers and scientists in the fields of biotechnology, automotive, architecture, electrical, electronic, photonic, optical, and sensor engineering.6-10 Printers' resolution is dropping under 100 micrometers (250 dot per inch (DPI)) with a typical layer thickness of 100 micrometers. The primary advantage of a 3D printer is its ability to create any shape in the micrometer range up to several meter range depending on the supporting holder.Over the past few years a rapid growth in the 3D printing industry has been observed as evidenced by the enormous numbers of articles published in scientific journals and patents filed as illustrated in Figure 1. Advances in the 3D printing technology will also lead to significant price drop, owing to the fact that a lot of items will be manufactured depending only upon the type and need of the customer. 11This means that household-level production will be much preferred due to broader imagination and creativity of human being. Another implication is that the manufacturing process of any item can be highly customized because altering the items will not require tooling or intensive software development.12 These simplified production processes that were...

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Disposable roll-to-roll hot embossed electrophoresis chip for detection of antibiotic resistance genemecA in bacteria

Cited by 53 publications

References 39 publications

Continuous separation of blood cells in spiral microfluidic devices

Continuous separation of blood cells in spiral microfluidic devices

Nanomanufacturing—Perspective and applications

Advances in 2D/3D Printing of Functional Nanomaterials and Their Applications

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