2023
DOI: 10.1021/acsapm.3c02295
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Disposable Saliva Sensors for Early Cancer Diagnosis Using Hyper-Cross-Linked Molecularly Imprinted Polymeric Electrocatalysts

Sadaf Athar,
Iqra Zaman,
Amna Liaqat
et al.
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Cited by 5 publications
(5 citation statements)
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“…A colored micrograph (Figure d) and the respective 3D image (Figure e) demonstrate a uniformly coated surface of the disposable electrodes. The corresponding surface profiles (Figure f) confirm the homogeneity of surface features, with sub-100 nm wide peaks and troughs, indicative of a rough leptokurtic surface . The formation of the composite Cre-PAni/Nb 2 O 5 structure is confirmed by transmission electron microscopy (TEM).…”
Section: Results and Discussionmentioning
confidence: 53%
See 1 more Smart Citation
“…A colored micrograph (Figure d) and the respective 3D image (Figure e) demonstrate a uniformly coated surface of the disposable electrodes. The corresponding surface profiles (Figure f) confirm the homogeneity of surface features, with sub-100 nm wide peaks and troughs, indicative of a rough leptokurtic surface . The formation of the composite Cre-PAni/Nb 2 O 5 structure is confirmed by transmission electron microscopy (TEM).…”
Section: Results and Discussionmentioning
confidence: 53%
“…The detailed procedures for the collection and pretreatment of human saliva samples are provided in the Experimental Section (Supporting Information). The recovery (%) of spiked Cre concentrations is calculated according to the following formula: Recovery (%) = ( C recovered / C spiked ) × 100; where C recovered = ( C total – C initial ). , …”
Section: Results and Discussionmentioning
confidence: 99%
“…19 This feature makes MIPs a valuable and sought-after research material, as an alternative to natural antibodies or enzymes, used for various applications such as sensors, separations, and catalysis. 20–22 Unlike natural receptors, MIPs are easy to generate, are robust in extreme conditions, possess good long-term storage stability, and can be easily synthesized for a variety of targets without laborious laboratory work. To enhance molecular recognition, the selection of suitable functional monomers and cross-linker units is essential, ensuring that the structure of the template molecule is aligned.…”
Section: Introductionmentioning
confidence: 99%
“…S2c † ), where the Nb 2 O 5 @MIP modified electrode shows deviation toward 40° demonstrating capacitive properties with surface defects and leakage current. 25 These defect sites pertain to imprints and cavities that may act as diffusion channels in Nb 2 O 5 @MIP nanoreceptors, promoting the electrocatalytic activity for sensitive detection of the target analyte. This is manifested in the greater voltammetric response of the Nb 2 O 5 @MIP modified electrode (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Separately, all saliva samples were spiked with 200 nM creatinine to investigate the differences in creatinine concentration and estimate the percent recovery of creatinine, as described elsewhere. 25 During the measurements, the saliva samples were stored below 8 °C.…”
Section: Methodsmentioning
confidence: 99%