Disposable Screen‐Printed Carbon Electrodes for Dual Electrochemiluminescence/Amperometric Detection: Sequential Injection Analysis of Oxalate

Chiu, Ming‐Chung; Wu, Han; Chen, Jyh-Cheng; Muthuraman, G.; Zen, Jyh‐Myng

doi:10.1002/elan.200703984

Cited by 21 publications

(13 citation statements)

References 19 publications

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“…The main disadvantages of electrochemiluminescence are the greater complexity of the detection cell (due to the need to incorporate two or three electrodes) and the possibility of electrode fouling 9, 24, 26. However, these issues have been somewhat overcome by the use of inexpensive screen‐printed electrodes that have the working, auxiliary, and reference electrodes printed on a disposable substrate 27…”

Section: Introductionmentioning

confidence: 99%

Chemiluminescence and electrochemiluminescence detection of controlled drugs

Adcock

Barrow

Barnett

et al. 2010

Drug Testing and Analysis

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We review the determination of various controlled drugs (opioids, tranquilizers, stimulants, and hallucinogens) using flow-analysis methodologies (flow injection analysis, high performance liquid chromatography, capillary electrophoresis, and microfluidic devices) with chemiluminescence and electrochemiluminescence reagents such as luminol, diaryloxalates, tris(2,2'-bipyridine)ruthenium(II), permanganate, manganese(IV), and sulfite, for industrial, clinical, pharmaceutical, and forensic science applications.

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Section: Introductionmentioning

confidence: 99%

Chemiluminescence and electrochemiluminescence detection of controlled drugs

Adcock

Barrow

Barnett

et al. 2010

Drug Testing and Analysis

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“…[1][2][3][4][5][6][7][8][9][10][11] In order to increase the automation of luminescent analytical procedures, the detection of ECL response by flow injection analysis system (FIA) is an interesting option. [12,13] Flow analysis is characterized by highly reproducible and throughput sampling. In addition, sequential injection analysis allows a considerable reduction in the consumption of the sample and reagents.…”

Section: A Miniaturized Flow Injection Analysis System For Electrogenmentioning

confidence: 99%

A Miniaturized Flow Injection Analysis System for Electrogenerated Chemiluminescence−Based Assays

et al. 2017

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A new miniaturized flow injection analysis (FIA) system for developing electrochemiluminescence (ECL)-based assays is presented. Novel thin-layer flowÀcell (TLFCL) screen-printed carbon electrodes integrated in one-channel flow cells were used as the electrode surface. These TLFCL electrodes, combined with miniaturized electrochemical and optical instrumentation, allowed a high degree of automation and simplicity of the assay. The performance of this high-throughput flow system was corroborated with a proof-of-concept centered on H 2 O 2 detection. For that purpose, an ECL transduction chemistry mechanism based on a electrochemiluminescence resonance energy transfer (ECL-RET) donorÀacceptor strategy, between an electro-oxidized luminophore (luminol) to a fluorophore (fluorescein), in the presence of the analyte of interest, was carried out. The results showed that fluorescein ECL-RET luminescent response increases the sensitivity of H 2 O 2 detection by up to one order of magnitude, in comparison with a luminolÀH 2 O 2 fluorescein-free assay. All experiments were performed in a decentralized, small-sized, easy-to-use FIA system coupled to ECL detection instrumentation.The light emitted from electrogenerated chemiluminescence (ECL) is a process in which electrochemically generated species combine to undergo electron-transfer reactions to form excited, light-emitting species, giving place to the development of high sensitive and selective assays. [1][2][3][4][5][6][7][8][9][10][11] In order to increase the automation of luminescent analytical procedures, the detection of ECL response by flow injection analysis system (FIA) is an interesting option. [12,13] Flow analysis is characterized by highly reproducible and throughput sampling. In addition, sequential injection analysis allows a considerable reduction in the consumption of the sample and reagents. [14] Bearing in mind that ECL based advances are moving towards the development of portable, high-throughput and point-of-care testing systems, [8,15] disposable screen-printed electrodes coupled to a small-sized, non-conventional, FIA system appears as an attractive possibility.For that purpose, in this work, screen-printed electrodes integrated in one channel flow-cell (TLFCL, Thin layer flow-cell) were used as the electrode surface. In these electrodes a transparent slide, that usefully allows the detection of air bubbles inside the cell, is attached over the screen-printed electrodes platform delimiting a flow channel. The injection of sample volume is done through an "in-line luer" injection port, placed closest to the electrochemical cell, where the injection can be easily controlled by operator through a precise syringe. This configuration brings important advantages since it simplifies operability and effectiveness of working in FIA systems. A similar format was already reported in two previous works [16,17] where enzymatic amperometric based sensors were developed. However, this is the first time that these electrodes, integrated in the necessary accessori...

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“…The ECL intensity is proportional to the concentrations of Ru(bpy) 3 2+ and co‐reactants, which can both be used for bioassays. Biomolecules usually act as an alternative co‐reactant to TPA, and can be detected in the presence of high, predetermined concentrations of ECL emitters, such as amines,58 drugs,59 and oxalate 60. Generally, tertiary amines are more effective co‐reactants than secondary and primary amines.…”

Section: Ecl Application In Bioanalysis Based On Ru(bpy)32+mentioning

confidence: 99%

Applications of tris(2,2′‐bipyridyl)ruthenium(II) in electrochemiluminescence

Li¹,

Wang²

2011

The Chemical Record

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Electrochemiluminescence (ECL) of tris(2,2'-bipyridyl)ruthenium(II) [Ru(bpy)(3)(2+)] has received considerable interest over broad applications due to its remarkably high sensitivity and extremely wide dynamic range. After a brief introduction of the ECL of Ru(bpy)(3)(2+), an overview of our recent research on enhanced ECL, fabrication of solid-state ECL sensors, analytical application of an effective bioassay, and alignment of ECL with capillary electrophoresis (CE) and microchip CE is discussed in detail. Finally, we conclude with a look at the future challenges and prospects of the development of ECL.

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Disposable Screen‐Printed Carbon Electrodes for Dual Electrochemiluminescence/Amperometric Detection: Sequential Injection Analysis of Oxalate

Cited by 21 publications

References 19 publications

Chemiluminescence and electrochemiluminescence detection of controlled drugs

Chemiluminescence and electrochemiluminescence detection of controlled drugs

A Miniaturized Flow Injection Analysis System for Electrogenerated Chemiluminescence−Based Assays

Applications of tris(2,2′‐bipyridyl)ruthenium(II) in electrochemiluminescence

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