Disposal of donor livers in Brazil: how to optimize their utilization rate in transplants?

Drezza, Júlia Porto de Oliveira; Boteon, Amanda Pinter Carvalheiro da Silva; Calil, Igor Lepski; Anna, Raoni Salomão Sant; Viveiros, Marcelo de Melo; Rezende, Marcelo Bruno de; Pecora, Rafael Antônio Arruda; Boteon, Yuri L.

doi:10.31744/einstein_journal/2021ao6770

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Other countries with a large population, including Brazil, China, and India, will enormously benefit from dynamic preservation techniques, provided that the technology achieves cost-effectiveness. Based on an often not standardized and suboptimal donor management (ie, treatment of central diabetes insipidus correcting for hypernatremia, lack of infectious disease screening, hemodynamic stabilization) frequently seen in such countries, the majority of donor's livers would classify as marginal and may benefit from MP and viability assessment 52 . The reason behind this is often the lack of official guidelines and center support provided by the national governing bodies of organ transplantation.…”

Section: What Is the Potential Market?mentioning

confidence: 99%

Obstacles to implement machine perfusion technology in routine clinical practice of transplantation: Why are we not there yet?

et al. 2023

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Machine perfusion of solid human organs is an old technique, and the basic principles were presented as early as 1855 by Claude Barnard. More than 50 years ago, the first perfusion system was used in clinical kidney transplantation. Despite the well-known benefits of dynamic organ preservation and significant medical and technical development in the last decades, perfusion devices are still not in routine use. This article describes the various challenges to implement this technology in practice, critically analyzing the role of all involved stakeholders, including clinicians, hospitals, regulatory, and industry, on the background of regional differences worldwide. The clinical need for this technology is discussed first, followed by the current status of research and the impact of costs and regulations.Considering the need for strong collaborations between clinical users, regulatory bodies, and industry, integrated road maps and pathways required to achieve a wider implementation are presented. The role of research development, clear regulatory pathways, and the need for more

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Section: What Is the Potential Market?mentioning

confidence: 99%

Obstacles to implement machine perfusion technology in routine clinical practice of transplantation: Why are we not there yet?

et al. 2023

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Solid Organ Donation Process: Correlation between Pro!le, Learning and Course Indication

Santos,

Calado,

Neto

et al. 2024

BJT

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Objectives: To understand the pro!le of professionals trained in the solid organ donation process, to analyze the result of their learning before and after the course, and to correlate the pro!le and the performance of the professional with the learning and indication of the course. Methods: Retrospective, quantitative, analytical-descriptive study with participants of the course Processo de Doação de Órgãos Sólidos para Pro!ssionais de Saúde. Online questionnaires were used on professional pro!le, performance in the area of organ donation, knowledge assessment, and course indication. "e analyses and correlations were veri!ed with the McNemar test, Spearman's rank, and the bisserial point. Results: Of the 130 professionals, 62% were nurses, 38% physicians, 35% emergency physicians, 26% intensivists, and 42% had more than 10 years of training. For the pro!le of work in the area of organ donation, the professionals report having participated in up to !ve cases in each of the following stages: 44% were involved in the brain death protocol, 56% in the family interview, and 60% in the organ donation process. "e class knowledge retention rate was 26.7%, with 29.5% for physicians and 24.8% for nurses. "e indication of the course was evaluated following the Net Promoter Score (NPS), being in the promoters zone. "e correlation between the groups was positive and statistically signi!cant for those working in the emergency room, with more than 5 years since graduation and with more than !ve cases reported on the questioned stages of organ donation. No signi!cant correlation was identi!ed between these variables and the indication of the course. Conclusion: "e course contributed to the learning of professionals with more training time, greater previous experience in the stages of the organ donation process, and working in the emergency sector.

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Processo de Doação de Órgãos Sólidos: Correlação entre Perfil, Aprendizagem e Indicação do Curso

Santos,

Calado,

Neto

et al. 2024

BJT

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Objetivos: Conhecer o perfil dos profissionais capacitados no processo de doação de órgãos sólidos, analisar o resultado de sua aprendizagem antes e após o curso, e correlacionar perfil e atuação do profissional com sua aprendizagem e indicação do curso. Métodos: Estudo retroprospectivo, quantitativo, analítico-descritivo com participantes do curso Processo de Doação de Órgãos Sólidos para Profissionais de Saúde. Utilizaram-se questionários online sobre perfil profissional, atuação na área de doação de órgãos, avaliação de conhecimento e indicação do curso. As análises e correlações foram verificadas com os testes de McNemar, postos de Spearman e ponto-bisserial. Resultados: Dos 130 profissionais, 62% eram enfermeiros, 38% médicos, 35% emergencistas, 26% intensivistas e 42% tinham mais de 10 anos de formação. Para o perfil de atuação na área de doação de órgãos, os profissionais relataram ter participado em até cinco casos em cada uma das seguintes etapas: 44% no protocolo de morte encefálica, 56% na entrevista familiar e 60% no processo de doação de órgãos. A taxa de retenção de conhecimento da turma foi de 26,7%, sendo a dos médicos 29,5% e a dos enfermeiros 24,8%. A indicação do curso foi avaliada seguindo o indicador Net Promoter Score (NPS), estando na zona de promotores. A correlação entre os grupos foi positiva e estatisticamente significante para os atuantes na emergência, com mais de 5 anos de formação e com mais de cinco casos relatados sobre as etapas questionadas na doação de órgãos. Não foi identificada correlação significativa dessas variáveis sobre a indicação do curso. Conclusão: O curso contribuiu para a aprendizagem dos profissionais com maior tempo de formação, maior experiência prévia nas etapas do processo de doação de órgãos e atuantes no setor de emergência.

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Disposal of donor livers in Brazil: how to optimize their utilization rate in transplants?

Cited by 3 publications

References 17 publications

Obstacles to implement machine perfusion technology in routine clinical practice of transplantation: Why are we not there yet?

Obstacles to implement machine perfusion technology in routine clinical practice of transplantation: Why are we not there yet?

Solid Organ Donation Process: Correlation between Pro!le, Learning and Course Indication

Processo de Doação de Órgãos Sólidos: Correlação entre Perfil, Aprendizagem e Indicação do Curso

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