Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod (<i>Gadus morhua</i>) and bullrout (<i>Myoxocephalus scorpius</i>) after single oral exposures

Ruus, Anders; Skaare, Janneche Utne; Ingebrigtsen, Kristian

doi:10.1002/etc.5620201033

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…The data showed that the concentrations of α-HCH were highest in fat, followed by brain and skin. As a result of its lipophilicity, α-HCH easily accumulates in tissues of high lipid content . A similar order of accumulation has been reported for α-HCH in mice and rabbits and for cis -/ trans -chlordane in cockerels .…”

Section: Resultssupporting

confidence: 75%

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Enantioselective Characteristics and Montmorillonite-Mediated Removal Effects of α-Hexachlorocyclohexane in Laying Hens

Liu

Shen

Wang

et al. 2016

Environ. Sci. Technol.

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α-Hexachlorocyclohexane (α-HCH) is a chiral organochlorine pesticide that is often ubiquitously detected in various environmental matrices and may be absorbed by the human body via food consumption, with serious detriments to human health. In this study, enantioselective degradation kinetics and residues of α-HCH in laying hens were investigated after a single dose of exposure to the pesticide, whereas enantioselectivity and residues of α-HCH in eggs, droppings, and various tissues were investigated after long-term exposure. Meanwhile, montmorillonite (MMT), a feed additive with high capacity of adsorption, was investigated for its ability to remove α-HCH from laying hens. Most non-brain tissues enantioselectively accumulated (-)-α-HCH, while (+)-α-HCH was preferentially accumulated in the brain. The enantiomer fractions (EFs) in most tissues gradually decreased, implying continuous depletion of (+)-α-HCH in laying hens. After 30 days of exposure and 31 days of elimination, the concentration of α-HCH in eggs and tissues of laying hens with MMT-containing feed was lower than that with MMT-free feed, indicating the removal effects of MMT for α-HCH in laying hens. The findings presented herein suggest that modified MMT may potentially be useful in reducing the enrichment of α-HCH in laying hens and eggs, thus lowering the risk of human intake of α-HCH.

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Section: Resultssupporting

confidence: 75%

“…In addition, the United States Environmental Protection Agency (U.S. EPA) has classified α-HCH as probable human carcinogens . As a result of its lipophilicity, α-HCH is easily accumulated in tissues of high fat content . Of all isomers, only α-HCH has a pair of enantiomers.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective Characteristics and Montmorillonite-Mediated Removal Effects of α-Hexachlorocyclohexane in Laying Hens

Liu

Shen

Wang

et al. 2016

Environ. Sci. Technol.

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“…Russell et al [30] reported that compounds with log K ow < 5.5 did not biomagnify in an aquatic food web of the Detroit River, and a model proposed by Thomann [31] indicates that for chemicals with log K ow < 5, decreased uptake and increased excretion will prevent biomagnification. Furthermore, Ruus et al [32] have shown that γ‐HCH fed to fish is rapidly eliminated, partly by biotransformation.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, some confusion may exist regarding the ability of fish to metabolize poly‐ ortho ‐substituted PCBs. However, metabolic modification of this type of congeners has been reported [32]. In addition, findings by Boon et al [28] and Bright et al [45] also suggest that CYP2B type metabolism is possible in fish since selective depletion of congeners with vicinal H‐atoms in metapara positions was observed.…”

Section: Discussionmentioning

confidence: 99%

Influence of trophic position on organochlorine concentrations and compositional patterns in a marine food web

Ruus

Ugland

Skaare

2002

Enviro Toxic and Chemistry

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The accumulation of polychlorinated biphenyls (PCBs), DDTs (p,p'-DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane], o,p'-DDT [1,1,1-trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane], p,p'-DDD [1,1,-dichloro-2,2-bis(4-chlorophenyl)ethane], o.p'-DDD [1,1-dichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane], and p,p'-DDE [1,1-dichloro-2,2-bis(4-chlorophenyl)ethene]), chlordanes (trans-chlordane, cis-chlordane, trans-nonachlor, cis-nonachlor and oxychlordane), hexachlorocyclohexanes (alpha-, beta-, and gamma-isomers), hexachlorobenzene, and mirex was investigated in a marine food web from southeastern Norway. The food web consisted of the polychaete Nereis diversicolor, lesser sandeel (Ammodytes tobianus), three species of gobys (Gobiusculus flavescens, Pomatoschistus sp., and Gobius niger), bullrout (Myoxocephalus scorpius), cod (Gadus morhua), herring gull (Larus argentatus), and harbor seal (Phoca vitulina). The results show that interspecies differences in organochlorine (OC) compositional patterns in the food web depend on several factors (allometric, biochemical, physical, and physicochemical) specific to both the chemicals and the organisms. The importance of dietary accumulation and metabolic capacity increases toward higher trophic levels, while the OC patterns are to a larger extent determined by the lipophilicity and water solubility of the compounds at lower trophic levels. Furthermore, stable nitrogen isotopes provided a continuous measure of trophic position, rendering us capable of quantifying the increases in the concentrations of sigma PCB, sigma dichorodiphenyltrichloroethane (DDT), and sigma chlordane (CHL) and the percentages of highly chlorinated PCBs through the food web. The information provided may be important for future modeling of the fate of organochlorine contaminants in marine food webs.

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“…Arctic marine zooplankton and benthic invertebrates do not appear to efficiently biotransform OCs, and concentrations and relative abundances of OCs in these organisms are mainly determined by exposure from water and diet and by direct elimination to water and fecal matter [23,25,92]. Based on laboratory studies, evidence suggest that both freshwater and marine fish can biotransform some OCs (see, e.g., [133,134]).…”

Section: Biotransformationmentioning

confidence: 99%

Biological and chemical factors of importance in the bioaccumulation and trophic transfer of persistent organochlorine contaminants in arctic marine food webs

Borgå

Fisk

Hoekstra

et al. 2004

Enviro Toxic and Chemistry

403

304

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Recent studies of arctic marine food webs have provided detailed insights regarding the biological and chemical factors that influence the bioaccumulation and trophic transfer of persistent organochlorine (OC) contaminants in aquatic systems. The present paper summarizes the recent literature with an emphasis on identifying important ecological factors for explaining variability of OC concentrations among organisms. The Arctic ecosystem has a number of unique attributes, including long food chains, reduced diversity of species, similar food webs across the entire region, and limited influence from pollution point sources. Lipid content, body size, age, gender, reproduction, habitat use, migration, biotransformation, seasonal changes in habitat conditions, feeding ecology, and trophic position have all been demonstrated to influence OC concentrations and bioaccumulation in arctic marine biota. The relative importance of each factor varies among OCs and organisms. Diet or trophic level is the dominant factor influencing OC concentrations and dynamics in seabirds and marine mammals, although biotransformation can significantly influence nonrecalcitrant OCs, such as hexachlorocyclohexane isomers. Dietary accumulation of OCs is also an important route of exposure for arctic fish and zooplankton, and biomagnification of OCs may also occur among these organisms. To date, only limited attempts have been made to model trophic transfer of OCs in the arctic marine food web. Although models developed to assess OC dynamics in aquatic food webs have included some biological variables (e.g., lipid content, feeding rate, diet composition, and growth rate), selection of processes included in these models as well as their mathematical solutions and parameterization all introduce simplification. This reduces biological validity of the models and may be particularly problematic in a highly seasonal environment, such as the Arctic Ocean.

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Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod (Gadus morhua) and bullrout (Myoxocephalus scorpius) after single oral exposures

Cited by 13 publications

References 31 publications

Enantioselective Characteristics and Montmorillonite-Mediated Removal Effects of α-Hexachlorocyclohexane in Laying Hens

Enantioselective Characteristics and Montmorillonite-Mediated Removal Effects of α-Hexachlorocyclohexane in Laying Hens

Influence of trophic position on organochlorine concentrations and compositional patterns in a marine food web

Biological and chemical factors of importance in the bioaccumulation and trophic transfer of persistent organochlorine contaminants in arctic marine food webs

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