Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck.

Abstract

1 Platinum concentrations in the tumour reached a peak of 3.8 ± 1.5 pLg g-1 wet weight tissue at the end of an 8 h intravenous infusion of cisplatin. The tumour concentrations of platinum were higher than the corresponding plasma concentrations (2.5 ± 0.9 ,g ml-') and declined more slowly.

Phase I trial of a cisplatin‐albumin complex for the treatment of cancer of the head and neck.

“…DeSimone et al (1987) reported biphasic kinetics of platinum in nine patients with a (t',2,z) of 19.5 to 24.9 h. In this study the terminal half-life in one patient (PM, Figure 1) was about 250 h, although samples were not taken over a long enough period in the other to allow an accurate assessment. The terminal half-lives found by DeSimone et al (1987) are shorter than would be expected from the known kinetics of platinum after conventional cisplatin and probably result from the collection of samples being made over too short a period (Holding et al, 1991) as illustrated by patient AR in this study (Figure 1). …”

“…We have previously shown that the median concentration of platinum in tumour biopsies after conventional cisplatin therapy was 3.4 j±g g-1 (Holding et al, 1991) and in all samples measured here the concentration found was greater than this.…”

“…The urinary excretion of platinum after the cisplatinalbumin complex was markedly less than after cisplatin alone with only 0.42% of the dose excreted during the infusion of the complex compared with 11.5% during conventional cisplatin therapy (Holding et al, 1991).…”

“…A single biopsy was taken from each patient with an accessible tumour mass with a 'tru-cut' needle after the infusion and was stored at -20°C until analyzed as described previously (Holding et al, 1991). Samples were diluted down to the linear range of the assay (0-0.2 ,ug ml-') when necessary with 0.2% (v/v) HNO3.…”

“…The concentration of platinum was measured by flameless atomic absorption spectrometry as described previously (Holding et al, 1991).…”