Disposition Kinetics of Difloxacin in Normal and Experimentally Infected Chickens With Mycoplasma Gallisepticum

Abstract

The pharmacokinetic properties of difloxacin were investigated following intravenous, intramuscular and oral administration of 10 mg/kg body weight, in non-infected and experimentally mycoplasma infected chickens. Serum concentrations of difloxacin were assayed microbialogically after intravenous, intramuscular and oral administrations. difl-oxacin residues were detected in chicken tissues following repeated oral administrations in non-infected and infected chickens. Following a single intravenous injection, the serum difloxacin level was best approximated to follow a two-compartment open model. The elimination half-life (t0.5) was 4.58 + 0.008 h. The volume of distribution at steady-state (Vdss) was 2.12 + 0.07 L/kg and the mean residence time (MRT) was 3.91 + 0.07 h.