1991
DOI: 10.1159/000480572
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Disposition of Cocaine in Pregnant Sheep: II. Physiological Responses

Abstract: We studied maternal and fetal blood pressure, heart rate, arterial blood gases and fetal behavioral state alterations in response to maternally administered cocaine hydrochloride in 11 pregnant sheep. Cocaine administration to the ewe caused a dose-dependent increase in maternal blood pressure and heart rate and in fetal blood pressure, and a decrease in fetal arterial oxygen tension. In the ewe, blood pressure changes corresponded linearly to dose administered (r = 0.88, p < 0.001). Blood pressure changes wer… Show more

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Cited by 17 publications
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“…The short half-life of cocaine in fetal sheep (4.5 min, DeVane et al, 1991) suggests that the drug would not be present in plasma in measurable amounts 3 days after exposure. During maternal exposure to cocaine, fetuses commonly become hypoxic (Woods et al, 1987;Burchfield et al, 1991b). Marked cerebral hypoxia in fetal lambs can result in delayed seizures (Williams et al, 1990).…”
Section: Discussionmentioning
confidence: 99%
“…The short half-life of cocaine in fetal sheep (4.5 min, DeVane et al, 1991) suggests that the drug would not be present in plasma in measurable amounts 3 days after exposure. During maternal exposure to cocaine, fetuses commonly become hypoxic (Woods et al, 1987;Burchfield et al, 1991b). Marked cerebral hypoxia in fetal lambs can result in delayed seizures (Williams et al, 1990).…”
Section: Discussionmentioning
confidence: 99%