Disposition of decoquinate-14C administered orally to chickens

Abstract

Single doses of decoquinate-3-14C were administered orally to colostomized chickens. Minor amounts (0.6 and 1.1 %) of radioactivity were excreted in the urine, but most of the radioactivity appeared in the feces or remained in the intestinal tract at 24 hr. Decoquinate-J-14C was orally administered to intact chickens for 3 successive days. The radioactivity was readily eliminated through the feces with no apparent retention of the compound. The radioactive components of the excreta were solubilized by successive extractions with ethanol and formic acid and were analyzed by thin-layer chromatography. Only 2.6% of the radioactive dose was metabolized to nondecoquinate components. The concentration of radioactivity in the bile was at least 30 times that in urine and blood. Thus, the bile appears to be implicated in the elimination of the absorbed compound. Decoquinate-14C given to chickens orally induced tissue residues throughout the bird body. When birds were medicated on successive days with decoquinate, a plateau of tissue residues occurred within 3 days. There was no accumulation of residue in any tissues examined.

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

“…Decoquinate is poorly absorbed from the GI tract of chickens, but what absorption occurs is rapid, and the drug is distributed widely to tissues (Filer et al. , 1969; Craine et al. , 1971).…”

“…Metabolism is not extensive, and excretion of the parent compound occurs via the faeces (Filer et al. , 1969; Craine et al. , 1971).…”

Metabolism of Decoquinate in Chickens and Japanese Quail

“…Decoquinate (DQ, ethyl 6-(decyloxy)-7-ethoxy-4-hydroxy-3-quinolinecarboxylate) has been approved as a dietary additive for use in nonlaying chickens, but not in quail. Limited metabolic data have been collected on DQ administered orally to chickens (Button et al, 1969;Craine et al, 1971), but not in quail. Metabolism of injected DQ has not been studied previously in either chickens or quail.…”

Synthesis and Anticoccidial Activities of Eight Novel Ethyl 7-Alkyl-6-(2-Aryloxyethoxy)-4-Hydroxyquinoline-3-Carboxylates

“…1, compound 2) has high anticoccidial activity when it is administered to chicken in the diet with a 27 mg kg −1 concentration. [11][12][13] However, the use of this drug has also declined because of the development of drug resistance. 5 We hope to find more novel compounds with anticoccidial activities, because the coccidia have developed resistance to the old structural compounds.…”