Disposition of inorganic mercury in pregnant rats and their offspring

Oliveira, Cláudia S.; Joshee, Lucy; Zalups, Rudolfs K.; Pereira, Maria Estér; Bridges, Christy C.

doi:10.1016/j.tox.2015.07.006

Cited by 31 publications

(23 citation statements)

References 40 publications

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“…Despite previous claims that Hg 2+ does not cross the blood–placental barrier, several in vivo and in vitro studies have provided evidence for the transport and accumulation of Hg 2+ in placentas and fetuses (Ask et al 2002; Inouye and Kajiwara 1990; Oliveira et al 2015). A recent study in pregnant Wistar rats exposed intravenously to two different doses of HgCl 2 showed that the accumulation of mercuric ions in the placental and fetal organs was dependent on the time of exposure and the dose to which pregnant rats were exposed (Oliveira et al 2015).…”

Section: Transport Of Inorganic Mercurymentioning

confidence: 93%

“…Numerous in vivo studies in rats have shown that mercuric ions accumulate in hepatocytes following exposure to HgCl 2 (Bridges et al 2008a, b, 2011, 2014, 2015; Oliveira et al 2016, 2015; Zalups 1993a, b). When mercuric ions are presented to the sinusoidal membrane of hepatocytes, they are most likely bound to non-protein thiols and plasma proteins, such as albumin, ferritin, and γ-globulins.…”

Section: Transport Of Inorganic Mercurymentioning

confidence: 99%

“…A recent study in pregnant Wistar rats exposed intravenously to two different doses of HgCl 2 showed that the accumulation of mercuric ions in the placental and fetal organs was dependent on the time of exposure and the dose to which pregnant rats were exposed (Oliveira et al 2015). Although maternal exposure to mercuric compounds during pregnancy can have significant detrimental effects on fetal development, the specific molecular mechanisms by which Hg 2+ is transported across placental syncytiotrophoblasts have not been well defined.…”

Section: Transport Of Inorganic Mercurymentioning

confidence: 99%

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Mechanisms involved in the transport of mercuric ions in target tissues

2016

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Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are taken up by and accumulate in numerous organs, including brain, intestine, kidney, liver, and placenta. In order to understand the toxicological effects of exposure to mercury, a thorough understanding of the mechanisms that facilitate entry of mercuric ions into target cells must first be obtained. A number of mechanisms for the transport of mercuric ions into target cells and organs have been proposed in recent years. However, the ability of these mechanisms to transport mercuric ions and the regulatory features of these carriers have not been characterized completely. The purpose of this review is to summarize the current findings related to the mechanisms that may be involved in the transport of inorganic and organic forms of mercury in target tissues and organs. This review will describe mechanisms known to be involved in the transport of mercury and will also propose additional mechanisms that may potentially be involved in the transport of mercuric ions into target cells.

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Section: Transport Of Inorganic Mercurymentioning

confidence: 93%

Section: Transport Of Inorganic Mercurymentioning

confidence: 99%

Section: Transport Of Inorganic Mercurymentioning

confidence: 99%

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Mechanisms involved in the transport of mercuric ions in target tissues

2016

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“…The prenatal exposure of methyl mercury, placenta being a very ineffective barrier, can result in negative fetal impact to central nervous system maturation. [10][11] Pregnant wistar rats showed that mercury is capable of crossing the placenta, accumulating in fetal organs notably highest concentration in kidney, succeeded liver and brain [12]. Similar to mercury, lead exposures in rats have a profound effect in their memory and overall cognition.…”

Section: Introductionmentioning

confidence: 99%

Study of Heavy Metals in Abnormal Growth and Development using an Alternate Animal Model: Heterometrus fulvipes

Rao¹,

Acharya²,

A³

et al. 2017

IJLSSR

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ABSTRACT-Background and Objectives:Heavy metals exposure in animals can lead to profound effects in growth and development. There have been incidences of various teratogenic effects in the past due to heavy metals exposure from various sources. The present study was conducted to access the effect of chronic heavy metals exposure in animal models. Materials and Methods: An experimental prospective study was performed with viviparous animal Heterometrus fulvipes to access the cumulative effect of chronic heavy metals exposure. H. fulvipes was exposed with mercury and lead; and effects monitored and documented in different times. Results: Chronic heavy metal exposure had considerable effects in mother and fetus of H. fulvipes. The effects in mother were represented by the loss of body weight and decrease in hepato-pancreatic weight and hepato-somatic index. Chronic exposure in fetus resulted in decrement in the embryonic length with subsequent reduction in the length and weight of embryos. Discussion: These studies and results of heavy metals in animal have proved the harmful effects of chronic heavy metal exposure with multitude of questions. The question of particular concern would be that how well animal teratology studies will predict the human hazard. The primary area of focus could be on the prevention of the birth defects induced by maternal exposure to heavy metals during pregnancy, as well as early prevention of teratogenic effects. Conclusion: It is necessary that the heavy metal toxicity be well documented in humans, and adequate precaution should be taken in mother and fetus to decrease its detrimental effects in the long run.

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“…The aim of this study was to evaluate in virgin, pregnant, and lactating rats the effects of HgCl 2 exposure and the different responses against inorganic Hg. Since it is known that the kidney is the primary site of accumulation of inorganic Hg in dams (Bridges and Zalups, ; Favero et al, ; Oliveira et al, ; Zalups, ), we investigated kidney morphology, ultrastructural characterization and expression of markers related to oxidative stress and cellular organelle alterations. Furthermore, due to the rapid uptake and accumulation of Hg by liver, besides kidneys, in the present study were evaluated also Hg hepatic alterations and oxidative stress induction.…”

Section: Introductionmentioning

confidence: 99%

Acute mercury exposition of virgin, pregnant, and lactating rats: Histopathological kidney and liver evaluations

Oliveira

Favero

Stacchiotti

et al. 2016

Environmental Toxicology

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This work investigated the effects of mercury chloride (HgCl ) acute exposure on virgin, pregnant and lactating rats by determination of renal and hepatic morphological and ultrastructural parameters and the expression of oxidative stress and stress tolerance markers, due to kidney and liver are the organs that more accumulate inorganic mercury. Adult Wistar rats virgin (90 days old), pregnant (18 gestation day) and lactating (7 lactation day) were injected once with HgCl (5 mg/kg) or saline (controls). We observed that HgCl exposure of virgin rats caused significant inflammatory infiltration and severe morphological variations, like glomeruli atrophy, dilatation of Bowman's capsule, tubular degeneration and hepatocytes alteration. Moreover, virgin rats presented mitochondrial modification, important oxidative stress and increase in stress tolerance proteins at both kidney and liver level, compared with virgin controls. In detail, virgin rats exposed to HgCl presented significantly elevated level of inducible nitric oxide synthase, heat shock protein 27 and glucose regulated proteins 75 expressions at both renal tubular and hepatocytes level, respect untreated virgin rats. Interestingly, pregnant and lactating rats exposed to HgCl presented weak renal and liver morphological alterations, showing weak inflammatory infiltration and no significant difference in structural mitochondrial transmembrane protein, oxidative stress markers and stress tolerance proteins expressions respect controls (virgin, pregnant and lactating rats). Although, both control and HgCl -exposed pregnant and lactating rats showed renal glomeruli greater in diameter respect virgin rats. In conclusion, we believe that virgin rats are more sensitive to HgCl toxicity respect pregnant and lactating rats. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1500-1512, 2017.

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Disposition of inorganic mercury in pregnant rats and their offspring

Cited by 31 publications

References 40 publications

Mechanisms involved in the transport of mercuric ions in target tissues

Mechanisms involved in the transport of mercuric ions in target tissues

Study of Heavy Metals in Abnormal Growth and Development using an Alternate Animal Model: Heterometrus fulvipes

Acute mercury exposition of virgin, pregnant, and lactating rats: Histopathological kidney and liver evaluations

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