Disposition of tetrachloro(14C)ethylene following oral and inhalation exposure in rats

Identification of Critical Biological Parameters Affecting Gastrointestinal Absorption

“…This is in contrast to experiments where dichloroethylene was administered in corn oil, in which peak concentrations in exhaled air were observed in 30 to 60 minutes (McKenna et al, 1978), and for tetrachloroethylene in corn oil, which yielded a peak blood concentration in 60 minutes (Pegg et al, 1979). Dosing of humans with chloroform in olive oil (Fry et al, 1972) also showed peak blood levels of this compound in 1 hour.…”

“…After the oral administration of volatile halogenated hydrocarbons, the time courses of both the blood concentration and the concentration of these chemicals in exhaled air exhibit biphasic decreases (Putcha et al, 1986;Chieco et al, 1981;D'Souza et al, 1985;McKenna et al, 1978;Pegg et al, 1979). from the GI tract in two phases, an initial rapid phase and a slower long-term phase, and effects of GI contents on both phases are apparent.…”

Effects of low-dose inhalation of three chlorinated aliphatic organic solvents on deoxyribonucleic acid in gerbil brain.

“…I, I, l-Trichloroethane is metabolized to a negligible extent (30, 3 1), cont rary to meth ylene chloride (3,13), while perch loro eth ylene is metabolized to so me extent (21,32). Thus local biotransfo rmat ion o f the so lvents in the central ner vous system could not explai n why I , I, I-trichlor oethane seems to have greater ef fects than meth ylene chloride and perchloroethylene.…”

Richtwerte für Tetrachlorethen in der Innenraumluft

“…Die Aufnahme ist proportional zur Ventilationsrate, der Expositionsdauer und der Konzentration von Tetrachlorethen in der Luft. Inhalationsstudien an Tieren bestäti-gen, dass Tetrachlorethen über die Lungen leicht resorbiert wird und anschließend systemisch vorliegt [7,11,12].…”