Suspendome integrates a lower cable-strut tensegrity system below the upper single-layer latticed dome for long span overlapping. Cable rupture, especially hoop cable failure, is an important failure mode that involves transient cable failure with significant impact. In this study, two kinds of cable rupture tests were conducted on a suspendome model to investigate the dynamic responses, failure modes, and mechanical changes. One was cable rupture at static loading state for simulating the practical cable break condition during the in-service period. The other was single hoop cable tension and rupture for exploring the influence of pretension level and cable-strut joint resistance. Results indicated that the stiffness and robustness of the suspendome were good such that no apparent deflection or failure phenomenon was observed. Cable rupture involved sudden tension failure, which led to the oscillatory response to adjacent strut members. Cable sliding occurred under large tension gaps, and it caused extensive tension loss throughout the entire hoop, thereby leading to different cable tension recovery patterns from non-slip numerical simulations. Cable rupture at the outmost ring had a larger impact and tension loss effect than that at the inner rings, and the extent of its influence on the suspendome was closely related to the tension levels and cable-strut joint characteristics.