2022
DOI: 10.3389/fmed.2021.770491
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Disrupted Circadian Rest-Activity Cycles in Inflammatory Bowel Disease Are Associated With Aggressive Disease Phenotype, Subclinical Inflammation, and Dysbiosis

Abstract: Patients with inflammatory bowel disease (IBD)—Crohn's disease (CD), and ulcerative colitis (UC), have poor sleep quality. Sleep and multiple immunologic and gastrointestinal processes in the body are orchestrated by the circadian clock, and we recently reported that a later category or chronotype of the circadian clock was associated with worse IBD specific outcomes. The goal of this study was to determine if circadian misalignment by rest-activity cycles is associated with markers of aggressive disease, subc… Show more

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Cited by 10 publications
(7 citation statements)
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“…Mucosal immune dysregulation has an important role in the alteration of the stomach's microbiota, as well as the disruption of the intestinal barrier function, which could drive the immune system to trigger a reaction to inflammatory processes. 12…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mucosal immune dysregulation has an important role in the alteration of the stomach's microbiota, as well as the disruption of the intestinal barrier function, which could drive the immune system to trigger a reaction to inflammatory processes. 12…”
Section: Discussionmentioning
confidence: 99%
“…11 Mucosal immune dysregulation has an important role in the alteration of the stomach's microbiota, as well as the disruption of the intestinal barrier function, which could drive the immune system to trigger a reaction to inflammatory processes. 12 As a result, there are unmet requirements to determine additional environmental factors which impact the subclinical inflammatory process of IBD. There are some coincidental examination findings which were incidentally identified in the period of or just before the asymptomatic IBD diagnosis and can facilitate early diagnosis, including extraintestinal manifestations of IBD, like inflammatory back pain, 13 chronic unexplained anemia, erythema nodosum, and venous thromboembolism, 14 which are also correlated to previously unrecognized IBD.…”
Section: Discussionmentioning
confidence: 99%
“…The dysregulation of the clock leads to dysregulated inflammation. Since inflammation can directly affect circadian rhythmicity, this constitutes a vicious cycle (44). We hope to use IL-6 as an example to provide research ideas for the study of circadian clock genes that regulate changes in airway inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…They also help to explain growing epidemiological evidence linking low circadian system robustness (usually judged by actigraphy or sleep fragmentation) to hospitalizations for a variety of ailments (92). For example, in inflammatory bowel disease circadian misalignment correlates with a more aggressive course of disease, increased intestinal permeability, elevated blood TNF-α, and elevated stool calprotectin levels, which are considered indicative of neutrophil migration and inflammation of the intestine (93). Conversely, clock gene expression is significantly reduced in patients with active ulcerative colitis compared with that in healthy controls and those in remission, suggesting that feedback regulation of intestinal circadian clocks might contribute to pathogenesis (94).…”
Section: Central and Peripheral Pacemakersmentioning
confidence: 99%