Disrupted default mode network and executive control network are associated with depression severity on structural network

Abstract

Objective Major depressive disorder (MDD) is a psychiatric disorder with a relatively limited response to treatment. It is necessary to better understand the neuroanatomical mechanisms of structural networks. MethodsThe current study recruited 181 first-onset, untreated adult MDD patients: slight MDD (SD, N = 23), moderate MDD (MD, N = 77), Heavy MDD (HD, N = 81) groups; along with a healthy control group (HC, N = 81) with matched general clinical data. FreeSurfer was used to preprocess T1 images for gray matter volume (GMV), and the default mode network (DMN) and the execution control network (ECN) were analyzed by structural covariance network (SCN). ResultsPresent study found that the GMV of brain regions reduced with the severity of the disease. Specifically, the GMV of the left anterior cingulate gyrus (ACC.L) is negatively correlated with MDD severity. In addition, the SCN connectivity of the whole-brain network increases with the increase of severity in MDD. ACC.L is a key brain region with increased connectivity between the left orbitofrontal in DMN and between the right orbitofrontal in ECN, which leads to damage to the balance of neural circuits. ConclusionsPatients with smaller GMV of ACC.L are more likely to develop severe MDD, and as a key region in both networks which have distinct structural network models in DMN and ECN. MDD patients with different severity have different neuroimaging changes in DMN and ECN.

Combined fractional anisotropy and subcortical volumetric deficits in patients with mild-to-moderate depression: Evidence from the treatment of antidepressant traditional Chinese medicine

“…It is worth noting that researchers have previously found that MDD patients with different severity have different neuroimaging changes in the default mode network (DMN) and the execution control network (ECN) (He et al, 2022 ). Thus, we divided patients with MMD into mild ( N = 24) and moderate ( N = 23) depression groups, and compared the GM volume and FA values of the two groups at baseline and 8 weeks of SG-treatment, respectively.…”

Proteomic Analysis of the Amygdala Reveals Dynamic Changes in Glutamate Transporter-1 During Progression of Complete Freund’s Adjuvant-Induced Pain Aversion

“…Emotional responses originate from the activation of specialised neuronal populations in several parts of the cerebral cortex, notably the ventromedial prefrontal, insula, anterior cingulate, and subcortical structures, such as the amygdala, nucleus accumbens, and ventral striatum [4][5][6][7][8]. The amygdala, located in the medial temporal lobe with an almond-shaped limbic structure, is well known for its role in assigning emotional significance to sensory inputs, affective and emotional states, and related behavioural adaptations [9][10][11][12][13].…”