2024
DOI: 10.1002/alz.14144
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Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock‐in mouse model of Alzheimer's disease

Andrés Norambuena,
Vijay Kumar Sagar,
Zhuoying Wang
et al.

Abstract: INTRODUCTIONReduced brain energy metabolism, mammalian target of rapamycin (mTOR) dysregulation, and extracellular amyloid beta (Aβ) oligomer (xcAβO) buildup are some well‐known Alzheimer's disease (AD) features; how they promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit nutrient‐induced mitochondrial activity (NiMA) in cultured neurons. We now report NiMA disruption in vivo.METHODSBrain energy metabolism and oxygen consumption were recorded in heterozygous amyloid prec… Show more

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