Disrupted network architecture of the resting brain in attention‐deficit/hyperactivity disorder

Sripada, Chandra; Kessler, Daniel; Fang, Yu; Welsh, Robert C.; Kumar, Krishan Prem; Angstadt, Mike

doi:10.1002/hbm.22504

Cited by 164 publications

(181 citation statements)

References 80 publications

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“…More specifically, decreased intrinsic segregation of the attention networks may alter the information exchange threshold between the two systems with VAN signals interrupting goal-directed task-relevant DAN activity. This is consistent with recent findings that increasingly point to VAN as the locus of attentional dyscontrol and enhanced distractibility in ADHD [27,61,62]. For instance, López et al [63] observed that in the ADHD group, but not in controls, unattended task-irrelevant distractors elicited increased VAN-related P300 activity.…”

Section: Discussionsupporting

confidence: 89%

“…Therefore, in the context of ADHD this might be hypothesized to relate to symptoms of distractibility and inability to ignore irrelevant stimuli. It is however difficult to directly compare our results with previous studies as a differentiation between the VAN and SN is often not made [62]. For instance, Sripada et al [62] did not differentiate between the VAN and SN and included insula as part of the VAN.…”

Section: Discussionmentioning

confidence: 70%

“…It is however difficult to directly compare our results with previous studies as a differentiation between the VAN and SN is often not made [62]. For instance, Sripada et al [62] did not differentiate between the VAN and SN and included insula as part of the VAN. We based our analyses on the model of the SN as a between-network switching hub, as proposed by Menon and Uddin [15], which is differentiated from the attentional networks.…”

Section: Discussionmentioning

confidence: 70%

“…The field has produced inconsistent results in this regard. While most studies have reported reduced DMN connectivity [37,38,44,62], hyperconnectivity has also been observed [40,41] (and one study found hyperconnectivity for some regions and hypoconnectivity for others within the DMN [65]. These inconsistencies may be due to differences between studies in analysis techniques used or sample characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…The finding of a stronger SN-DAN anti-correlation in the control group, as well as a trend towards SN-VAN hyperconnectivity in the ADHD group, suggests a decreased brain network functional differentiation and adds to the frameworks where deficits in between brain networks balance are proposed to underlie ADHD. The trend to SN-VAN hyperconnectivity in ADHD suggests that attentional control deficits may be tentatively associated with VAN alterations [61,62].…”

Section: Discussionmentioning

confidence: 99%

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Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Sidlauskaite

Sonuga‐Barke

Roeyers

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesized to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six minutes resting state scans were obtained. Using a network-based approach, connectivity within and between the dorsal and ventral attention, the default mode and the salience networks was compared between the ADHD and control group.The ADHD group displayed hyperconnectivity between the two attention networks and within the default mode and ventral attention network. The salience network was hypoconnected to the dorsal attention network. There were trends towards hyperconnectivity within the dorsal attention network and between the salience and ventral attention network in ADHD.Connectivity within and between other networks was unrelated to ADHD. Our findings highlight the altered connectivity within and between attention networks, and between them and the salience network in ADHD. One hypothesis to be tested in future studies is that individuals with ADHD are affected by an imbalance between ventral and dorsal attention systems with the former playing a dominant role during task engagement making individuals with ADHD highly susceptible to distraction by salient task-irrelevant stimuli.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Sidlauskaite

Sonuga‐Barke

Roeyers

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Growth Charting of Brain Connectivity Networks and the Identification of Attention Impairment in Youth

2016

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Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents

Sato

Biazoli

Salum

et al. 2015

Human Brain Mapping

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Abnormal connectivity patterns have frequently been reported as involved in pathological mental states. However, most studies focus on "static," stationary patterns of connectivity, which may miss crucial biological information. Recent methodological advances have allowed the investigation of dynamic functional connectivity patterns that describe non-stationary properties of brain networks. Here, we introduce a novel graphical measure of dynamic connectivity, called time-varying eigenvector centrality (tv-EVC). In a sample 655 children and adolescents (7-15 years old) from the Brazilian "High Risk Cohort Study for Psychiatric Disorders" who were imaged using resting-state fMRI, we used this measure to investigate age effects in the temporal in control and default-mode networks (CN/DMN). Using support vector regression, we propose a network maturation index based on the temporal stability of tv-EVC. Moreover, we investigated whether the network maturation is associated with the overall presence of behavioral and emotional problems with the Child Behavior Checklist. As hypothesized, we found that the tv-EVC at each node of CN/DMN become more stable with increasing age (P < 0.001 for all nodes). In addition, the maturity index for this particular network is indeed associated with general psychopathology in children assessed by the total score of Child Behavior Checklist (P = 0.027). Moreover, immaturity of the network was mainly correlated with externalizing behavior dimensions. Taken together, these results suggest that changes in functional network dynamics during neurodevelopment may provide unique insights regarding pathophysiology.

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Disrupted network architecture of the resting brain in attention‐deficit/hyperactivity disorder

Cited by 164 publications

References 80 publications

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Growth Charting of Brain Connectivity Networks and the Identification of Attention Impairment in Youth

Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents

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