Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder

Parenti, Mariana; Slupsky, Carolyn M

doi:10.1016/j.advnut.2024.100279

Advances in Nutrition

2024

DOI: 10.1016/j.advnut.2024.100279

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Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder

Mariana Parenti,

Carolyn M Slupsky

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Cited by 2 publications

References 152 publications

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Antioxidant vitamins’ modification of the adverse health effects induced by phthalate exposure: A scoping review of epidemiological and experimental studies

Mo,

Shan,

Chen

et al. 2024

Ecotoxicology and Environmental Safety

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Antioxidant vitamins’ modification of the adverse health effects induced by phthalate exposure: A scoping review of epidemiological and experimental studies

Mo,

Shan,

Chen

et al. 2024

Ecotoxicology and Environmental Safety

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Neurodevelopment of Autism: Critical Periods, Stress and Nutrition

Ayoub

2024

Cells

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Autism spectrum disorder (ASD) is a neurodevelopmental disability that presents significant challenges in communication and behavior. ASD prevalence exceeds 2% among eight-year-old children and is at similar levels globally. We propose that critical periods during fetal development and early postnatal years establish the conditions for either neurotypical development or the emergence of autism through mechanisms that influence immune function or delay neuronal development. One critical period is characterized by the requirement for folate, a crucial methyl donor needed for DNA regulation. Insufficient folate availability has been linked to the risk of developing ASD. Another critical period may be affected by oxidative stress or inflammation of the fetal brain, potentially due to inadequate microglial immunity, which can lead to CNS inflammatory changes that disrupt typical neurodevelopment. We suggest that early supplementation with reduced folate and taurine during both the fetal and postnatal stages may be effective in mitigating the severity of ASD symptoms by promoting neurotypical development through these critical neurodevelopmental periods.

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Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder

Cited by 2 publications

References 152 publications

Antioxidant vitamins’ modification of the adverse health effects induced by phthalate exposure: A scoping review of epidemiological and experimental studies

Antioxidant vitamins’ modification of the adverse health effects induced by phthalate exposure: A scoping review of epidemiological and experimental studies

Neurodevelopment of Autism: Critical Periods, Stress and Nutrition

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