Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead

Baranowska-Bosiacka, Irena; Gutowska, Izabela; Marchlewicz, Mariola; Marchetti, Carla; Kurzawski, Mateusz; Dziedziejko, Violetta; Kolasa, Agnieszka; Olszewska, Maria; Rybicka, Marta; Safranow, Krzysztof; Nowacki, Przemysław; Wiszniewska, Barbara; Chlubek, Dariusz

doi:10.1016/j.brainres.2011.11.062

Cited by 62 publications

(37 citation statements)

References 52 publications

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“…The group that received ferrous sulfate alone also suggest this because they showed lower enzyme activity than the control group. These results are consistent with the literature, such as the study by Baranowska‐Bosiacka et al (), which assessed rat brains exposed to lead at concentrations below 10 (μg/g tissue). In another study (Moneim et al, ) of rat brains exposed to 20‐mg/kg lead acetate for 5 days by intraperitoneal injection (10 μL), a significant decrease in GPx activity was observed compared to controls.…”

Section: Discussionsupporting

confidence: 93%

“…However, Adonaylo and Oteiza () recorded an increase in SOD activity in animal brains exposed to lead. In a recent study, Baranowska‐Bosiacka et al () evaluated the activity of SOD1 and SOD2 and found decreased levels of SOD2 activity in different brain regions of rats exposed to lead, similar to our study. Interesting findings included decreased concentrations of selenium, zinc, copper, and manganese in the brain.…”

Section: Discussionsupporting

confidence: 90%

“…In this study, analysis of the mean concentrations of lead (Pb 2+ ) in whole blood and the brain demonstrated a dose–response profile, which was similar to results reported in the literature (Baranowska‐Bosiacka et al, ). Notably (Baranowska‐Bosiacka et al, ), the lead levels were analyzed in different anatomical regions of the brain, with minor differences among the regions tested. Recently, another group also described the heterogeneous accumulation of lead in different brain regions (Guimaraes et al, ).…”

Section: Discussionsupporting

confidence: 88%

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Influence of iron on modulation of the antioxidant system in rat brains exposed to lead

et al. 2016

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The objective of this study was to evaluate markers of oxidative stress in the brains of rats exposed to lead acetate (Pb(C H O ) ), either associated or not associated with ferrous sulfate (FeSO ). A total of 36 weaning rats (Rattus norvegicus) were divided into 6 groups of six animals and exposed to lead acetate for six weeks. In the control group (control), the animals received deionized water. The Pb260 and Pb260 + Fe received 260 µM lead acetate, and the Pb1050 and Pb1050 + Fe received 1050 µM lead acetate. The Pb260 + Fe and Pb1050 + Fe were supplemented with 20 mg of ferrous sulfate/Kg body weight every 2 days. Group Fe received deionized water and ferrous sulfate. The rat brains were collected to analyze the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the concentration of reduced glutathione (GSH), lipid peroxidation (TBARS), and total antioxidant substance (TAS) (DPPH technique). The activity of SOD and GPx in the experimental groups decreased compared to the control, together with the concentration of GSH (p < 0.05). For CAT analysis, SOD tended to increase in concentration in the experimental groups without a concomitant exposure to FeSO , whereas GPx showed a slight tendency to increase in activity compared to the control. For TAS-DPPH , there was a decrease in the experimental groups (p < 0.05). According to the results, SOD, GPx, and GSH were affected by lead acetate and exposure to ferrous sulfate changed this dynamic. However, further studies are needed to verify whether ferrous sulfate acts as a protectant against the toxic effects of lead. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 813-822, 2017.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

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Influence of iron on modulation of the antioxidant system in rat brains exposed to lead

et al. 2016

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“…Hippocampus and cerebellum are affected by PM direct exposure. Likewise, previous data show no oxidative stress caused by heavy metals to brain areas, but hippocampus (Baranowska-Bosiacka et al, 2012). Zanchi et al (2010a) showed that chronic intranasal inhalation of ROFA (a highcontent metal PM) develops oxidative stress in the hippocampus of rats, but it does not affect the functionality of this structure.…”

Section: Discussionmentioning

confidence: 89%

Direct contact with particulate matter increases oxidative stress in different brain structures

Fagundes

Fleck

Zanchi

et al. 2015

Inhalation Toxicology

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“…Induction of CYP1A1 expression by AhR ligation is well documented; its downstream signal mediates cellular responses probably through modifying cytokine secretion, including IL-6 [84], IL-17, and IL-22 [37, 82, 85]. Induction of oxidative stress has been reported in case of Pb 2+ [86], Cd 2+ [87–89], and Hg 2+ exposure [90], inferred by reduced activity of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and reduction of glutathione (GSH). Smoking, a major source of Cd [91], also initiates ROS production accompanied by augmented cell signaling pathways implicated in the pathogenesis of AD such as psoriasis that implicates mitogen-activated protein kinase (MAPK), NF- κ B and Janus kinase JAK/STAT [92], and reduced antioxidants malondialdehyde and SOD [93].…”

Section: Th17 Cells Are Key Players In Heavy-metal-elicited Autoimmentioning

confidence: 99%

The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation

Hemdan

El-Saad

Sack

2013

Clinical and Developmental Immunology

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Extensive research in recent years suggests that exposure to xenobiotic stimuli plays a critical role in autoimmunity induction and severity and that the resulting response would be exacerbated in individuals with an infection-aroused immune system. In this context, heavy metals constitute a prominent category of xenobiotic substances, known to alter divergent immune cell responses in accidentally and occupationally exposed individuals, thereby increasing the susceptibility to autoimmunity and cancer, especially when accompanied by inflammation-triggered persistent sensitization. This perception is learned from experimental models of infection and epidemiologic studies and clearly underscores the interplay of exposure to such immunomodulatory elements with pre- or postexposure infectious events. Further, the TH17 cell subset, known to be associated with a growing list of autoimmune manifestations, may be the “superstar” at the interface of xenobiotic exposure and autoimmunity. In this review, the most recently established links to this nomination are short-listed to create a framework to better understand new insights into TH17's contributions to autoimmunity.

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Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead

Cited by 62 publications

References 52 publications

Influence of iron on modulation of the antioxidant system in rat brains exposed to lead

Influence of iron on modulation of the antioxidant system in rat brains exposed to lead

Direct contact with particulate matter increases oxidative stress in different brain structures

The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation

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