2023
DOI: 10.1038/s44161-023-00365-0
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Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Kyung Chan Park,
Nicholas T. Crump,
Niamh Louwman
et al.

Abstract: Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism result in histone modifications and changes to gene expression that affect cardiac function. Plasma propionate surrogates were raised in PA mice, but female hearts manifested more profound changes in acyl-CoAs, histone propionylation and acetylation, and transcription. These resulted in moderate dia… Show more

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