Disrupted white matter integrity in depressed versus non-depressed Parkinson's disease patients: A tract-based spatial statistics study

Huang, Peiyu; Xu, Xiaojun; Gu, Quanquan; Xuan, Min; Yu, Xinfeng; Luo, Wei; Zhang, Minming

doi:10.1016/j.jns.2014.08.011

Cited by 51 publications

(74 citation statements)

References 34 publications

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“…Firstly, WMLs might cause a dysfunction of the orbitofrontal lobe, which is associated with the regulation of mood and emotion. Secondly, the disconnection of the frontal cortex from the limbic-striatal area caused by WMLs could disable the function of the amygdala and eventually lead to emotional instability [26]. Similar to the preceding reports, out results support a negative impact of WMLs on mood disorders including depression and anxiety.…”

Section: Discussionsupporting

confidence: 79%

“…Recently, a considerable number of studies have elucidated that WMLs have a negative impact not only on motor symptoms of PD, including postural instability and gait disturbance, but also on cognitive impairment and depression [8-10, 26]. In this study, we investigated the relationship between WMLs and the symptoms of PD, including non-motor symptoms as well as motor symptoms and cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Petrovic et al [10] reported that the burden of PVH and DWMH related to frontostriatal dysfunction was correlated with the severity of depression in PD. Huang et al [26] demonstrated a negative correlation between WMLs and depression in two ways. Firstly, WMLs might cause a dysfunction of the orbitofrontal lobe, which is associated with the regulation of mood and emotion.…”

Section: Discussionmentioning

confidence: 99%

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Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease

et al. 2018

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Background: There are only few studies exploring the relationship between white matter lesions (WMLs) and non-motor symptoms in Parkinson disease (PD). This study aimed to investigate the association between WMLs and the severity of non-motor symptoms in PD. Methods: The severity of motor dysfunction, cognitive impairment, and non-motor symptoms was assessed by various scales in 105 PD patients. We used a visual semiquantitative rating scale and divided the subjects into four groups: no, mild, moderate, and severe WMLs. We compared the means of all scores between the four groups and analyzed the association between the severity of WMLs and the specific domain of non-motor symptoms. Results: The non-motor symptoms as assessed by the Non-Motor Symptoms Scale, Parkinson’s Disease Questionnaire (PDQ-39), Parkinson’s Disease Sleep Scale, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Neuropsychiatric Inventory (NPI), and Parkinson Fatigue Scale (PFS) were significantly worse in the patients with moderate and severe WMLs than in those without WMLs. Compared with the no WML group, the scores for motor dysfunction were significantly higher in the mild, moderate, and severe WML groups. The scores for cognitive dysfunction were significantly higher in the patients with severe WMLs than in those without WMLs. The severity of WMLs showed linear associations with PFS, BDI, BAI, NPI, and PDQ-39 scores. The severity of WMLs also correlated linearly with scores for motor and cognitive dysfunction. Conclusions: Among the non-motor symptoms, fatigue, depression, anxiety, and quality of life were significantly affected by WMLs in PD. Confirmation of the possible role of WMLs in non-motor symptoms associated with PD in a prospective manner may be crucial not only for understanding non-motor symptoms but also for the development of treatment strategies.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease

et al. 2018

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“…Of the 38 studies on depression, 33 reported findings from one single imaging modality: 19 used either PET [11, 12, 13,15, 16, 17, 18, 19] or SPECT 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 techniques, four used T1‐weighted imaging 31, 32, 33, three used DTI 34, 35, 36, six used resting state functional MRI (RS‐FMRI) 37, 38, 39, 40, 41, 42 and two used TCS methods 43, 44. The remaining four of the 38 studies reported findings from structural T1‐weighted imaging plus another imaging method, including PET 14, DTI 45, task FMRI 46 and RS‐FMRI 47, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The other two studies applying TCS demonstrated hypoechogenicity in the brainstem raphe in dPD patients as opposed to HCs and non‐depressed PD patients 43, 48. Using DTI techniques, three out of four studies reported compromised white matter connectivity indexed by decreased fractional anisotropy (FA) in various tracts, including the bilateral anterior cingulate cortex and thalamus and multiple tracts connecting to the left frontal and deep temporal lobes 34, 35, 36. However, one study reported a non‐significant group difference in the FA of the corpus callosum and uncinate fasciculus, a tract that interconnects the amygdala, hippocampus, temporal pole and the orbitofrontal cortex 45.…”

Section: Methodsmentioning

confidence: 99%

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Wen

Chan

Tan

et al. 2016

Euro J of Neurology

150

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Depression, anxiety and apathy are common mood disturbances in Parkinson's disease (PD) but their pathophysiology is unclear. Advanced neuroimaging has been increasingly used to unravel neural substrates linked to these disturbances. A systematic review is provided of neuroimaging findings in depression, anxiety and apathy in PD. A PubMed, MEDLINE and EMBASE search of peer‐reviewed original research articles on these mood disturbances in PD identified 38 studies on depression, eight on anxiety and 14 on apathy in PD. Most of the imaging studies used either position emission tomography or single‐photon emission computed tomography techniques. These studies generally suggest increased neural activity in the prefrontal regions and decreased functional connectivity between the prefrontal−limbic networks in depressed patients. Functional imaging studies revealed an inverse correlation between dopaminergic density in the caudate and putamen with the severity of anxiety in PD. There was no consistent correlation between dopaminergic density of thalamus and anxiety. Studies demonstrated both positive and inverse correlations between apathy and metabolism or activity in the striatum, amygdalar, prefrontal, temporal and parietal regions. The clinical variability of study subjects and differences in image pre‐processing and analytical strategies may contribute to discrepant findings in these studies. Both nigrostriatal and extra‐nigrostriatal pathways (in particular the frontal region and its connecting areas) are affected in mood disorders in PD. Identifying the relative contributions of these neural pathways in PD patients with overlapping motor and mood symptoms could provide new pathophysiological clues for the development of better therapeutic targets for affected patients.

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Diffusion tensor imaging correlates of depressive symptoms in Parkinson disease

Uhr

Tsolaki

Pouratian

2022

J of Comparative Neurology

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Award Number: R01NS097782Depression is a heterogeneous clinical syndrome prevalent in patients with Parkinson disease (PD) that remains incompletely understood. Further, the differences in biomarkers of depression in PD and in non-PD patients are unclear. The subcallosal cingulate cortex (SCC) and its connections have been implicated in the pathophysiology of major depressive disorder (MDD). Diffusion tensor imaging (DTI) provides a tool to quantify MDD-related structural abnormalities underlying depressive symptoms in PD. Diffusion-weighted magnetic resonance imaging data were collected from 31 patients with PD. Depression symptom severity was measured using the Beck Depression Inventory (BDI-II), and assessed using three subscales: dysphoric mood, loss of interest/pleasure, and somatic symptoms. Probabilistic tractography methods were used to quantify the SCC connectivity to target regions in cortico-limbic-striatal network (ventral striatum, medial prefrontal cortex [mPFC], dorsal anterior cingulate cortex, and uncinate fasciculus), while fractional anisotropy (FA) was calculated in predefined white matter regions of interest. DTI data were correlated with severity of depression across three domains. SCC-mPFC connectivity in the left hemisphere was positively correlated with severity of dysphoric mood (Benjamini-Hochberg adjusted p = .02). Region of interest-based analyses demonstrated a significant and distinct topographic association between FA and dysphoric mood, loss of interest/pleasure, and somatic symptom severity, although these findings did not maintain significance after applying the false discovery rate correction. Abnormal SCC connectivity underlies depressive symptoms in both PD and MDD, suggesting that interventions used for MDD should be explored in treating depressive symptoms in PD, particularly depression dominated by dysphoric mood.

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Disrupted white matter integrity in depressed versus non-depressed Parkinson's disease patients: A tract-based spatial statistics study

Cited by 51 publications

References 34 publications

Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease

Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Diffusion tensor imaging correlates of depressive symptoms in Parkinson disease

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