This paper relates urban healthcare crises to the global challenges of overshoot and collapse and suggests systems thinking as an innovative approach towards addressing these amalgamated crisis situations. We begin by reviewing what systems are and how they are structured and behave, highlighting how systems thinking can identify high-leverage interventions and systemic design to achieve effective change. Subsequently, we illustrate how these system concepts were applied in an international, multidisciplinary summer school between European and Southeast Asian partners in collaboration with the World Health Organization’s (WHO) Technical Science for Health Network (Téchne). Examining how ventilation, temperature, humidity, and daylighting control strategies enhance Infection Prevention and Control (IPC), the initiative developed ideas and designs for a multiple disease treatment center that would provide isolation units and create a safe care environment for patients, families, and communities. The design process was informed through consultation with three physically and socio-economically diverse neighborhoods across the Bangkok Metropolitan Region to gain a richer understanding of the varied experiences and approaches in managing the COVID-19 disruption. Leveraging WHO guidelines, students adopted a systemic design approach to develop innovative solutions that could withstand natural hazards and used local materials and natural ventilation to prevent airborne infection and control indoor temperature. In conclusion, we propose a novel working model linking specific stages of systemic thinking and systemic design into a generalized, iterative urban and healthcare design framework that will be further refined as part of specific electives at the KU Leuven Faculty of Architecture and joint summer schools in 2023, 2024 and beyond.