Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals

Thambirajah, Anita A.; Wade, Michael G.; Verreault, Jonathan; Buisine, Nicolas; Alves, Verônica Angélica; Langlois, Valérie S.; Helbing, Caren C.

doi:10.1016/j.envres.2021.111906

Cited by 36 publications

(22 citation statements)

References 222 publications

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“…A number of high-profile environmental pollutants adversely affect the TH system of different species. The hypothalamic–pituitary–thyroidal (HPT) axis is highly conserved among vertebrate phyla, and THs play crucial roles in the regulation of vertebrate development as well as important homeostatic processes associated with growth and energy metabolism . However, suitable end points for the detection of chemicals that interfere with the HPT axis have not been established in nonmammals, except for amphibian metamorphosis. , In teleosts, disruption of the HPT axis reportedly causes a wide variety of adverse effects, including impacts on development and visual performance, as well as malformation of the swim bladder in zebrafish. , However, assessment of these effects is impeded by limited information regarding defined TH-dependent phenomena, including TH-dependent gene expression.…”

Section: Introductionmentioning

confidence: 99%

Preself-Feeding Medaka Fry Provides a Suitable Screening System for in Vivo Assessment of Thyroid Hormone-Disrupting Potential

Myosho

Ishibashi

Fujimoto

et al. 2022

Environ. Sci. Technol.

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Endocrine-disrupting chemicals are assessed based on their physiological potential and their potential associated adverse effects. However, suitable end points for detection of chemicals that interfere with the thyroid hormone (TH) system have not been established in nonmammals, with the exception of amphibian metamorphosis. The aims of the current study were to develop an in vivo screening system using preself-feeding medaka fry (Oryzias latipes) for the detection of TH-disrupting chemicals and elucidate the underlying molecular mechanism. 17α-Ethinylestradiol (EE2: <100 ng/L) did not induce mRNA expression of estrogen-responsive genes, vitellogenins (vtgs) mRNA. Meanwhile, coexposure with thyroxin (T4) induced an increase of vtg expression. TH-disrupting chemicals (thiourea (TU), perfluorooctanoic acid (PFOA), and tetrabromobisphenol A (TBBPA)) significantly suppressed EE2 (1,000 ng/L)-induced vtg1 expression, while T4 rescued their expression as well as that of thyroid hormone receptor α (tRα) and estrogen receptors (esrs). These results were supported by in silico analysis of the 5′-transcriptional regulatory region of these genes. Furthermore, the esr1 null mutant revealed that EE2-induced vtg1 expression requires mainly esr2a and esr2b in a TH-dependent manner in preself-feeding fry. Application of preself-feeding medaka fry as a screening system might help decipher the in vivo mechanisms of action of TH-disrupting molecules, while providing an alternative to the traditional animal model.

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Section: Introductionmentioning

confidence: 99%

Preself-Feeding Medaka Fry Provides a Suitable Screening System for in Vivo Assessment of Thyroid Hormone-Disrupting Potential

Myosho

Ishibashi

Fujimoto

et al. 2022

Environ. Sci. Technol.

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“…EDCs are EP classes that include phthalates, polybrominated compounds, polychlorinated biphenyls (PCBs), steroid sex hormones, pesticides, pharmaceutical products, bisphenol A (BPA), alkylphenol ethoxylates, and alkylphenols. When a mother is exposed to EDCs such as BPA and phthalates, the sexual development of her offspring can be hampered [82][83][84]. Diethyltoluamide/insect repellents (DEET), ultraviolet (UV) screens, synthetic musk fragrances, and parabens are types of PCPs that may also act as EDC in water [81,[85][86][87][88][89].…”

Section: Toxicological Effects Of Epsmentioning

confidence: 99%

A Review on Emerging Pollutants in the Water Environment: Existences, Health Effects and Treatment Processes

Arman

Salmiati

Aris

et al. 2021

Water

122

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Emerging pollutants (EPs), also known as micropollutants, have been a major issue for the global population in recent years as a result of the potential threats they bring to the environment and human health. Pharmaceuticals and personal care products (PPCPs), antibiotics, and hormones that are used in great demand for health and cosmetic purposes have rapidly culminated in the emergence of environmental pollutants. EPs impact the environment in a variety of ways. EPs originate from animal or human sources, either directly discharged into waterbodies or slowly leached via soils. As a result, water quality will deteriorate, drinking water sources will be contaminated, and health issues will arise. Since drinking water treatment plants rely on water resources, the prevalence of this contamination in aquatic environments, particularly surface water, is a severe problem. The review looks into several related issues on EPs in water environment, including methods in removing EPs. Despite its benefits and downsides, the EPs treatment processes comprise several approaches such as physico-chemical, biological, and advanced oxidation processes. Nonetheless, one of the membrane-based filtration methods, ultrafiltration, is considered as one of the technologies that promises the best micropollutant removal in water. With interesting properties including a moderate operating manner and great selectivity, this treatment approach is more popular than conventional ones. This study presents a comprehensive summary of EP’s existence in the environment, its toxicological consequences on health, and potential removal and treatment strategies.

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“…Halogenated flame retardants (HFRs) such as polybrominated diphenyl ethers (PBDEs) and other HFRs, including replacement chemicals known as emerging HFRs, have been reported at high levels in SLE beluga blubber. These chemicals are known to disrupt the regulation of thyroid and steroid hormones in a range of experimental animal models and wildlife species including marine mammals (Zhang et al, 2016;Thambirajah et al, 2022). Recently, studies have examined the metabolomic profiles of SLE belugas with respect to organohalogen contaminant exposure and identified potential mechanisms of toxicity and metabolic disruption (Simond et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Investigating the relationship between the skin microbiome and flame retardant exposure of the endangered St. Lawrence Estuary beluga

Jia

Garlock²,

Allison³

et al. 2022

Front. Environ. Sci.

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The endangered beluga (Delphinapterus leucas) population in the St. Lawrence Estuary (SLE) in eastern Canada, the largest estuary in the world, is declining. Elevated tissue concentrations of a wide range of environmental contaminants, for example, halogenated flame retardants (HFRs) including polybrominated diphenyl ethers (PBDEs), might play a role in the non-recovery of this population. In mammals, HFRs have been reported to impair the metabolic regulation, including amino acid and fatty acid pathways. In the present study, we collected both blubber and skin swab samples from tissue biopsies from 56 adult SLE belugas and analyzed their blubber for the concentrations of a comprehensive suite of PBDEs and other HFRs. Using 16S rRNA marker and shotgun metagenomic approaches using skin swabs, we investigated, for the first time, the SLE beluga skin microbiome and the SLE water microbiome, providing valuable comparative taxonomic and functional microbiome information. We found that belugas have a unique skin microbiome that is distinct from surrounding SLE water, regardless of the beluga sex or location in the SLE. We further characterized the core microbiome of SLE beluga skin and surrounding SLE water, and identified bacterial taxa and gene functional pathways associated with the skin microbiome that correlated with beluga blubber HFR concentrations. Namely, we identified the phylum Nitrospinae and candidate phylum PAUC34f as potential taxa of interest that are associated with blubber HFR concentrations. We hypothesize that the biodegradation of HFRs within the beluga blubber and skin results in an increase in local metabolite concentrations that leads to the proliferation of Nitrospinae and PAUC32f. This work demonstrates the utility of studying the core microbiome of the SLE beluga skin using a swab method that could be adapted to field sampling. Further studies of the temporal effects of contaminant exposure on SLE beluga skin and SLE water microbiomes is warranted for potentially better monitoring and protecting this marine mammal which is at risk.

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Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals

Cited by 36 publications

References 222 publications

Preself-Feeding Medaka Fry Provides a Suitable Screening System for in Vivo Assessment of Thyroid Hormone-Disrupting Potential

Preself-Feeding Medaka Fry Provides a Suitable Screening System for in Vivo Assessment of Thyroid Hormone-Disrupting Potential

A Review on Emerging Pollutants in the Water Environment: Existences, Health Effects and Treatment Processes

Investigating the relationship between the skin microbiome and flame retardant exposure of the endangered St. Lawrence Estuary beluga

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