“…PI3K-Akt governs many downstream signaling pathways involved in protein synthesis, glucose metabolism, cell proliferation and survival, and angiogenesis, and alterations of these pathways are frequent occurrences in cancers (Vivanco and Sawyers, 2002;Hamada et al, 2005;Yuan and Cantley, 2008). Recent reports indicate that activation of the PI3K-Akt-signaling pathway is involved in neuroblastoma progression, and its activation also predicts poor prognosis in primary neuroblastoma (Yaari et al, 2005;Chesler et al, 2006;Ishola et al, 2007;Opel et al, 2007;Kang et al, 2008). In addition, PI3K-Akt induces stabilization of MYCN protein (Yaari et al, 2005;Chesler et al, 2006).…”