Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans

Hua, Xin; Wang, Dayong

doi:10.1016/j.envpol.2023.122649

Cited by 28 publications

(1 citation statement)

References 66 publications

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“…Caenorhabditis elegans exhibits high susceptibility to pollutant toxicity [ 23 , 24 , 25 , 26 ], which makes it suitable for assessing the toxicity of pollutants at PEDs [ 27 , 28 , 29 ]. Meanwhile, C. elegans has a relatively short life cycle [ 30 ], which makes it suitable to evaluate transgenerational toxicity after pollutant exposure [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans

Liu,

Wang,

Bian

et al. 2024

Toxics

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Transgenerational nanoplastic toxicity could be detected in Caenorhabditis elegans after exposure at the parental generation (P0-G); however, the underlying mechanisms remain largely unclear. We aimed to examine the role of germline nuclear hormone receptors (NHRs) in controlling the transgenerational toxicity of polystyrene nanoparticles (PS-NPs) based on gene expression screening and functional analysis. Among germline NHR genes, daf-12, nhr-14, and nhr-47 expressions were increased and nhr-12 expression was decreased by PS-NPs (1 and 10 μg/L). Transgenerational alterations in expressions of these four NHR genes were also induced by PS-NPs (1 and 10 μg/L). RNAi of daf-12, nhr-14, and nhr-47 caused resistance, whereas RNAi of nhr-12 conferred susceptibility to transgenerational PS-NP toxicity. After PS-NP exposure, expressions of ins-3, daf-28, and ins-39 encoding insulin ligands, efn-3 encoding Ephrin ligand, and lin-44 encoding Wnt ligand, as well as expressions of their receptor genes (daf-2, vab-1, and/or mig-1), were dysregulated by the RNAi of daf-12, nhr-14, nhr-47, and nhr-12. Therefore, alteration in certain germline NHRs could mediate the induction of transgenerational nanoplastic toxicity by affecting secreted ligands and their receptors in the offspring of exposed organisms.

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