Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review

Guo, Wenli; Zhang, Jie; Li, Wenjun; Xu, Ming; Liu, Sijin

doi:10.1016/j.jes.2015.04.004

Cited by 30 publications

(22 citation statements)

References 128 publications

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“…Unfortunately, reports are not available as to whether this affects iron homeostasis and health in Tibetans. On the other hand, it is well-known that other environmental pollutants derived from soil and drinking water, such as persistent organic pollutants, heavy metals, and pesticides, significantly affect body iron homeostasis with toxic effects on organic functions [115]. Finally, the habit of open-fire cooking has to be considered as a source of iron pollution, too.…”

Section: Environmental Factors That Impact Lung Iron Homeostasismentioning

confidence: 99%

Iron Homeostasis in the Lungs—A Balance between Health and Disease

et al. 2019

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A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function. Imbalances in pulmonary iron homeostasis are frequently associated with respiratory diseases, such as chronic obstructive pulmonary disease and with lung cancer. However, the underlying mechanisms causing alterations in iron levels and the involvement of iron in the development of lung disorders are incompletely understood. Here, we review current knowledge about the regulation of pulmonary iron homeostasis, its functional importance, and the link between dysregulated iron levels and lung diseases. Gaining greater knowledge on how iron contributes to the pathogenesis of these diseases holds promise for future iron-related therapeutic strategies.

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Section: Environmental Factors That Impact Lung Iron Homeostasismentioning

confidence: 99%

Iron Homeostasis in the Lungs—A Balance between Health and Disease

et al. 2019

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“…A large number of papers have reported on the detection, through liquid chromatography coupled to mass spectrometry [2], of many different classes of SOC in surface water [3], even after treatment at municipal wastewater treatment plants, such as: herbicides, antibiotics, personal care products, and so on [4,5]. In the environment, such compounds can cause severe damage to aquatic and human lives [6], and thus their effects need further investigation. Consequently, there is the necessity to adequately treat effluents, using distinct methods or their combination [7], before disposal in the environment.…”

Section: Introductionmentioning

confidence: 99%

On the performance of a hybrid process to mineralize the herbicide tebuthiuron using a DSA® anode and UVC light: A mechanistic study

Montes

Silva²,

Aquino

2017

Applied Catalysis B: Environmental

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A hybrid electrochemical and photochemical (HEP) process was used to oxidize and mineralize the herbicide tebuthiuron (TBT), which is a potential contaminant of ground water, using a DSA ® anode and UVC light. The electrochemical and photochemical experiments were carried out in flow reactors and the investigated variables were: i) power of the Hg lamp (5, 9, 80, and 125 W), ii) solution pH (3, 7, 11, and no control), iii) NaCl concentration (0, 1, 2, and 4 g L −1), and iv) electric current density (10, 20, and 30 mA cm −2). The performance of the oxidation and mineralization process of TBT and its intermediates was assessed by high performance liquid chromatography coupled to mass spectrometry and total organic carbon analyses. The use of a 9 W Hg lamp led to complete oxidation and mineralization of TBT, and its intermediate compounds, from acidic to neutral solutions, independently of the applied electric current density, and with increasing NaCl concentration. High CO 2 conversions were obtained using the HEP process, as the generated intermediates (including an organochlorine) were completely eliminated. TBT removal rates similar to those of an electrochemical experiment using a boron-doped diamond anode were attained using the HEP process, but with higher energy consumption; however, chlorinated carboxylic acids were no longer present in the final treatment stages. The HEP process could be regarded as an advanced oxidation process, being an interesting option to treat effluents contaminated with organics if a proper optimization of the UVC lamp is done.

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“…Iron is an essential element involved in various biological processes including oxygen transport, electron transport and various enzymatic reactions such as DNA synthesis, transcriptional regulation, catalysis as well as nitric oxide (NO) and oxygen sensing [ 48 ]. Several research studies demonstrated that deregulated cellular and systemic iron metabolism would lead to cytotoxicity and increased risk for various diseases, including nephrotoxicity and renal cancer [ 49 , 50 ]. In addition, it was demonstrated that iron induced tissue lipid peroxidation, apoptosis, and formation of 8-hydroxydeoxyguanosine, a known DNA oxidative modification [ 50 ].…”

Section: Results Discussionmentioning

confidence: 99%

Heavy Metal Accumulation is Associated with Molecular and Pathological Perturbations in Liver of Variola louti from the Jeddah Coast of Red Sea

Mohamed

Elshal

Kumosani

et al. 2016

IJERPH

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Large amounts of waste water are discharged daily from the Jeddah Metropolitan Area into the Red Sea. Sewage draining into the Red Sea causes widespread chemical pollution that is toxic to aquatic ecosystems. The objective of this study was to investigate the extent of pollution and assess the presence of heavy metals in fish tissue and study their association with biological and biochemical alterations. The average concentrations of heavy metals found in hepatic tissues of Variola louti fish from the polluted area, namely Cd, Cr, Cu, Fe and Zn, were 1.74, 9.69, 47.48, 4020.01 and 229.47 µg/g liver, respectively, that were significantly higher than that of samples taken from reference area (0.24, 1.98, 20.12, 721.93, 129.21 µg/g liver, respectively). The fold change of heavy metals in fish from the polluted area with respect of that of the reference area followed the order Cd > Fe > Cr > Cu > Zn. Analysis of nuclear DNA revealed that hepatic tissues of fish samples from the polluted area showed a significant increase in apoptotic cells as detected by flow cytometry and formation DNA-ladder. In addition, hepatic sections from polluted area fishes showed more fibrotic changes and collagen deposition by hematoxylin-eosin staining and Masson’s trichrome staining, respectively, compared to samples taken from the reference area. Moreover, the electrophoretic patterns of proteins of liver of fishes caught at the polluted area showed different patterns of proteins from that of the reference with bands at 42, 130 and 140 kDa, which is in a good agreement with the molecular weight of collagen type III. In conclusion, there were significant changes in the tissues of fishes in the polluted area at the cellular and the molecular levels that may be associated with an accumulation of heavy metals. Assessment of fishes as a sensitive biomonitor for the pollution of surface waters that may affect general health of human and wild life is conceivable.

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Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review

Cited by 30 publications

References 128 publications

Iron Homeostasis in the Lungs—A Balance between Health and Disease

Iron Homeostasis in the Lungs—A Balance between Health and Disease

On the performance of a hybrid process to mineralize the herbicide tebuthiuron using a DSA® anode and UVC light: A mechanistic study

Heavy Metal Accumulation is Associated with Molecular and Pathological Perturbations in Liver of Variola louti from the Jeddah Coast of Red Sea

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