Disruption of Jmjd3/p16Ink4a Signaling Pathway Causes Bizarre Parosteal Osteochondromatous Proliferation (BPOP)-like Lesion in Mice

Zhang, Feng; Wang, Yingmei; Wang, Yuying; Wang, Xinli; Zhang, Dawei; Zhao, Xiaodong; Jiang, Runmin; Gu, Yu; Yang, Guorui; Fu, Xin; Xu, Longyong; Xu, Liguang; Zheng, Liting; Zhang, Jing; Li, Zengshan; Qu, Yan; Shi, Jing; Roessner, Albert; Wang, Zhe; Ye, Jing; Chen, Charlie Degui; Guo, Shuangping; Min, Jie

doi:10.1002/jbmr.4401

Cited by 3 publications

(1 citation statement)

References 49 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 27 In addition, an animal experiment indicated that the Jmjd3/p16 Ink4a signaling pathway might play an important role in the development of BPOP. 28 Although the above studies suggest some therapeutic targets for BPOP, no specific drug is applied in the clinical setting. Because BPOP is a slowly growing benign lesion, conservative treatment is suggested when patients have no symptoms.…”

Section: Discussionmentioning

confidence: 99%

Bizarre parosteal osteochondromatous proliferation (Nora lesion) involving the spine: a case report and systematic review

Chen,

Wei,

Liu

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

Bizarre parosteal osteochondromatous proliferation (BPOP), also termed Nora lesion, is a rare, benign tumor most often located in the hands and feet. We herein present the second reported case of BPOP affecting the spine, an uncommon location. One year after surgical excision, the patient was pain-free and showed no evidence of recurrence. We reviewed a total of 323 cases of BPOP among 101 articles, providing the first systematic update on the latest knowledge of BPOP. The age of patients with BPOP ranges from 3 months to 87 years, peaking in the second and third decades of life. The hands are the most common location of BPOP (58.39%), followed by the feet (20.81%). Imaging features play a key role in the diagnosis of BPOP, but histopathologic diagnosis remains the gold standard. Differential diagnosis of BPOP should be based on the epidemiologic and clinical features as well as clinical examination findings. Surgical resection is the most extensively used treatment for BPOP. Recurrence is common (37.44%) and can be treated with re-excision. This article can deepen our understanding of BPOP and will be helpful for the diagnosis and treatment of BPOP in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Bizarre parosteal osteochondromatous proliferation (Nora lesion) involving the spine: a case report and systematic review

Chen,

Wei,

Liu

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

show abstract

Ezh2 Inactivation is Essential for the Initiation of Metachondromatosis-Like Lesion in Mice

Zhang,

Dong,

Shen

et al. 2023

Preprint

View full text Add to dashboard Cite

Bizarre parosteal osteochondromatous proliferation or Nora’s lesion affecting the extremities: A concise update

Dharmshaktu

Agarwal

et al. 2022

JMSR

View full text Add to dashboard Cite

The bizarre parosteal osteochondromatous proliferation or Nora’s lesion is an unusual clinical entity that presents with localized swelling and pain. The characteristic radiological appearance includes a cluster of variably calcified lesions adjacent to a particular bone. However, it does not necessarily have direct continuity with its medullary region. The etiopathogenesis of this disorder is not yet fully understood. Various other lesions require careful exclusion and the use of advanced imaging modalities to supplement the diagnosis. The final diagnosis of the lesion, however, is based on the histopathological basis. However, these lesions are reported as sporadic reports or small series in the literature and are also discovered in areas other than the common locations in hands and feet. The recent research aims to throw more advanced knowledge into their causation, including genetic etiology. The symptomatic lesions may require excision for clinical relief, but recurrence is not uncommon. The future research, and preferably multi-center collaboration, is required for more insight into their comprehensive nature and clinical spectrum. A brief and crisp update of the articles published in the past 10 years describing bizarre parosteal oseochondromatous proliferation in the extremities is presented here for educational purposes for orthopedists and generalists alike.

show abstract

Disruption of Jmjd3/p16Ink4a Signaling Pathway Causes Bizarre Parosteal Osteochondromatous Proliferation (BPOP)-like Lesion in Mice

Cited by 3 publications

References 49 publications

Bizarre parosteal osteochondromatous proliferation (Nora lesion) involving the spine: a case report and systematic review

Bizarre parosteal osteochondromatous proliferation (Nora lesion) involving the spine: a case report and systematic review

Ezh2 Inactivation is Essential for the Initiation of Metachondromatosis-Like Lesion in Mice

Bizarre parosteal osteochondromatous proliferation or Nora’s lesion affecting the extremities: A concise update

Contact Info

Product

Resources

About