Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

Schneider‐Maunoury, Sylvie; Topilko, Piotr; Seitanidou, Tania; Levi, Giovanni; Cohen-Tannoudji, Michel; Pournin, Sandrine; Babinet, Charles; Charnay, Patrick

doi:10.1016/0092-8674(93)90329-o

Cited by 432 publications

(263 citation statements)

References 40 publications

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“…1) are absent in mutants. Specification of the nVII, nIX, and nX neurons and axonal pathfinding is not affected in mutant embryos, consistent with the normal development of the rhombomeres (r4, r6, r7, and caudal hindbrain) within which these neuronal populations arise (Swiatek and Gridley, 1993;Schneider-Maunoury et al, 1993. However, caudal migration of nVII motor neurons from r4 is defective due to the absence of r5 (Garel et al, 2000; see also Studer, 2001).…”

Section: Krox20mentioning

confidence: 77%

Turning heads: Development of vertebrate branchiomotor neurons

Chandrasekhar

2003

Developmental Dynamics

164

204

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The cranial motor neurons innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. These efferent neurons develop at characteristic locations in the brainstem, and their axons exit the neural tube in well-defined trajectories to innervate target tissues. This review is focused on a subset of cranial motor neurons called the branchiomotor neurons, which innervate muscles derived from the branchial (pharyngeal) arches. First, the organization of the branchiomotor pathways in zebrafish, chick, and mouse embryos will be compared, and the underlying axon guidance mechanisms will be addressed. Next, the molecular mechanisms that generate branchiomotor neurons and specify their identities will be discussed. Finally, the caudally directed or tangential migration of facial branchiomotor neurons will be examined. Given the advances in the characterization and analysis of vertebrate genomes, we can expect rapid progress in elucidating the cellular and molecular mechanisms underlying the development of these vital neuronal networks.

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Section: Krox20mentioning

confidence: 77%

Turning heads: Development of vertebrate branchiomotor neurons

Chandrasekhar

2003

Developmental Dynamics

164

204

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“…A, Avr II, B, BgI II, E, EcoRI, S, Spe I. (B) Southern blot analysis of several clones of transfected ES cell line CK35 (Schneider-Maunoury et al, 1993) with the 3Ј probe. The wild type allele generates a 7.2-kb fragment, and the mutant allele generates a 11.8-kb fragment.…”

Section: Methodsmentioning

confidence: 99%

“…Embryos and newborns were X-gal stained as described (Schneider-Maunoury et al, 1993) and, for stages older than E10.5, clarified as previously reported (Levi et al, (Gu et al, 1993), followed by a polyadenylation site (pA) and a positive selection cassette (PGK-Neo). The Cre gene is therefore placed under the control of the Krox-20 regulatory elements.…”

Section: Methodsmentioning

confidence: 99%

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Expression pattern of aKrox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system

Voiculescu

Charnay

Schneider‐Maunoury

2000

genesis

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156

182

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“…It belongs to a multigene family encoding closely related transcription factors, including Krox-20 (Egr-2), Egr-3, and NGFI-C (Egr-4), which have been implicated in diverse processes in a variety of cell types, including cell growth, differentiation and apoptosis in response to extracellular stimuli (Gashler and Sukhatme, 1995). For example, Zif268-deficient mice derived from embryonic stem cells demonstrated female infertility due to the absence of luteinizing hormone transcription by pituitary cells (Lee et al, 1996) and Krox-20-deficient mice have defects in hindbrain development and differentiation of Schwann cells and osteoblasts (Schneider-Maunoury et al, 1993;Swiatek and Gridley, 1993;Topilko et al, 1994;Levi et al, 1996). Zif268, however, does not appear to be required for growth and differentiation of embryonic stem cells (Lee et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

2002

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ABSTRACT:The immediate-early gene Zif268 is a member of the Egr family of inducible transcription factors. Data from gene expression studies have suggested that this gene may play a critical role in initial triggering of the genetic machinery that has long been considered a necessary mechanism for maintenance of the later phases of LTP and also for the consolidation or stabilization of long-lasting memories. Until recently, however, the data supporting this assumption have been based primarily on circumstantial evidence, with no direct evidence to suggest that Zif268 is required for long-lasting synaptic plasticity and memory. In this report, we review our own data using Zif268 mutant mice; we show that although the early phase of dentate gyrus LTP is normal in these mice, the later phases are not present, and the ability of the mice to maintain learned information over a 24-h period is deficient. In addition, we present new information showing a task-dependent gene dosage effect in Zif268 heterozygous mice. We show that spatial learning is particularly sensitive to reduced levels of Zif268, as one-half of the complement of Zif268 in heterozygous mice is insufficient to maintain spatial long-term memories.

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Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

Cited by 432 publications

References 40 publications

Turning heads: Development of vertebrate branchiomotor neurons

Turning heads: Development of vertebrate branchiomotor neurons

Expression pattern of aKrox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system

Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

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