Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt(<scp>iv</scp>) prodrugs for cancer treatment

Sun, Peng; Wang, Jia-Qian; Xie, Qiang; Ren, Xuan-Lin; Qiao, Xin; Xu, Jing-Yuan

doi:10.1039/d4qi00386a

Inorg. Chem. Front.

2024

DOI: 10.1039/d4qi00386a

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Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt(iv) prodrugs for cancer treatment

Peng Sun,

Jia-Qian Wang,

Qiang Xie

et al.

Abstract: Ferroptosis is an iron-mediated regulated cell death initiated by excessive membrane lipid peroxide accumulation. The intimate interplay between ferroptosis and lipid metabolism suggests that modulating lipid metabolism and activating ferroptosis...

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Cited by 2 publications

References 72 publications

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Enhanced Sonodynamic Therapy for Deep Tumors Using a Self-Assembled Organoplatinum(II) Sonosensitizer

Wang,

Li,

Wang

et al. 2024

J. Med. Chem.

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Despite the promising advances in photodynamic therapy (PDT), it remains challenging to target and treat deepseated solid tumors effectively. Herein, we developed an organoplatinum(II) complex (Pt-TPE) with self-assembly properties for sonodynamic therapy (SDT). Pt-TPE forms a nanofiber network structure through Pt−Pt and π−π stacking interactions. Notably, under ultrasound (US), Pt-TPE demonstrates unique selfassembly-induced singlet oxygen ( 1 O 2 ) generation due to a significantly enhanced singlet−triplet intersystem crossing (ISC). This generation of 1 O 2 occurs exclusively in the self-assembled state of Pt-TPE. Additionally, Pt-TPE exhibits sono-cytotoxicity against cancer cells by impairing mitochondrial membrane potential (MMP), inhibiting glucose uptake, and aerobic glycolysis. Furthermore, US-activated Pt-TPE significantly inhibits deep solid tumors in mice, achieving remarkable therapeutic efficacy even at penetration depths greater than 10 cm. This study highlights the potential of self-assembled metal complexes to enhance the efficacy of SDT for treating deep tumors.

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Enhanced Sonodynamic Therapy for Deep Tumors Using a Self-Assembled Organoplatinum(II) Sonosensitizer

Wang,

Li,

Wang

et al. 2024

J. Med. Chem.

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Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity

Guo,

Liang,

Liu

et al. 2024

J. Med. Chem.

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Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt(iv) prodrugs for cancer treatment

Abstract: Ferroptosis is an iron-mediated regulated cell death initiated by excessive membrane lipid peroxide accumulation. The intimate interplay between ferroptosis and lipid metabolism suggests that modulating lipid metabolism and activating ferroptosis...

Cited by 2 publications

References 72 publications

Enhanced Sonodynamic Therapy for Deep Tumors Using a Self-Assembled Organoplatinum(II) Sonosensitizer

Enhanced Sonodynamic Therapy for Deep Tumors Using a Self-Assembled Organoplatinum(II) Sonosensitizer

Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity

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