Disruption of maternal behavior and appearance of cannibalism after ventral mesencephalic tegmentum lesions

Gaffori, Odile; Moal, Michel Le

doi:10.1016/0031-9384(79)90373-1

Cited by 121 publications

(53 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrolytic (Galfori and Le Moal, 1979;Numan and Smith, 1984) or 6-hydroxydopamine (Hansen et al, 1991(Hansen et al, , 1993 lesions of the VTA or the n. Acc greatly disrupt maternal behavior. Infusion of the mixed D 1 -D 2 receptor antagonist flupenthixol into the n. Acc significantly reduces pup LG (Keer and Stern, 1999).…”

Section: Discussionmentioning

confidence: 99%

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

332

257

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

332

257

View full text Add to dashboard Cite

show abstract

“…Johns et al (2004) found that gestational treatment with fluoxetine (a serotonin reuptake inhibitor) resulted in a reduction in oxytocin receptor affinity and an upregulation of oxytocin receptor number in the amygdala. Several brain regions are suggested as being relevant to maternal behavior and/or aggression in the rat, including the medial preoptic area (MPOA), ventral tegmental area (VTA), hippocampus, and amygdala, and reductions in oxytocin in these areas correlate with deficits in maternal behavior and/or aggression (Ferris et al, 1992;Gaffori and Le Moal, 1979;Johns et al, 1995Johns et al, , 1997Kimble et al, 1967;Lubin et al, 2003b;Numan and Smith, 1984;Numan, 1994a,b).…”

Section: Introductionmentioning

confidence: 99%

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Johns

Joyner

McMurray

et al. 2005

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Studies using dopaminergic and serotonergic agonists or antagonists implicate involvement of these systems in various aspects of early maternal behavior and postpartum aggression towards an intruder in rats, both of which are associated with the presence of oxytocin in specific brain regions. It is unclear however, if or how long-term uptake inhibition of either neurotransmitter system alone or in combination, affects oxytocin system dynamics or maternal behavior/ aggression. Pregnant women frequently take drugs (antidepressants, cocaine) that induce longterm reuptake inhibition of dopamine and/or serotonin, thus it is important to understand these effects on behavior and biochemistry. Rat dams were treated throughout gestation with amfonelic acid, fluoxetine, or a combination of both, to investigate effects of reuptake inhibition of dopamine and serotonin systems respectively, on maternal behavior, aggression and oxytocin. The more appetitive aspects of maternal behavior (nesting, licking, touching) and activity were increased by the low dose of amfonelic acid, high dose of fluoxetine, or the high dose combination more than other treatments. Aggression was decreased by amfonelic acid and somewhat increased by fluoxetine. Dopamine uptake inhibition appears to have a strong effect on hippocampal oxytocin levels, while receptor dynamics may be more strongly affected by serotonin uptake inhibition.

show abstract

“…For example, dopamine is released (Hansen, et al, 1993) and c-fos is activated in the NAc (Lonstein et a., 1998) in maternal females following exposure to pups. This idea is further supported by the findings that VTA or NAc lesions can disrupt maternal behavior (Gaffori and Le Moal, 1979; Hansen, et al, 1991). It is also important to note that administration of low or high doses of cocaine can disrupt normal maternal behavior in rats (Morrell et al, 2011).…”

Section: Introductionmentioning

confidence: 63%

Stress, sex, and addiction

Bisagno

Cadet

2014

Behavioural Pharmacology

View full text Add to dashboard Cite

Stress sensitivity and gender are predictive factors for the development of neuropsychiatric disorders. Life stresses are not only risk factors for the development of addiction but they are also triggers for relapse to drug use. Therefore, it is imperative to elucidate the molecular mechanisms underlying the interactions between stress and drug abuse, because this understanding may help in the development of novel and more effective therapeutic approaches to block the clinical manifestations of drug addiction. The development and clinical course of addiction-related disorders do appear to involve neuroadaptations within neurocircuitries that modulate stress responses and are influenced by several neuropeptides. These include corticotropin releasing factor (CRF), the prototypic member of this class, as well as oxytocin (OXY) and arginine-vasopressin (AVP) that play important roles in affiliative behaviors. Interestingly, these peptides function to balance emotional behaviors in a sexual dimorphism of OXY/AVP systems, a fact that might play an important role in the differential responses of women and men to stressful stimuli and the specific gender-based prevalence of certain addictive disorders. Thus, this review aims to summarize (1) the contribution of sex differences to the function of dopamine systems, and (2) the behavioral, neurochemical, and anatomical changes in brain stress systems.

show abstract

Disruption of maternal behavior and appearance of cannibalism after ventral mesencephalic tegmentum lesions

Cited by 121 publications

References 34 publications

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Stress, sex, and addiction

Contact Info

Product

Resources

About