DOI: 10.21248/gups.74656
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Disruption of p54nrb's gene regulatory function by caspase-2 exhibits a multifaceted role in tumor cell death susceptibility

Abstract: Caspase-2 is the evolutionary most conserved member of the caspase family and was shown to be involved in genotoxic stress induced apoptosis, control of aneuploidy, and ageing related metabolic changes. However, its role in apoptosis seems redundant due to the observation, that knockout does not inhibit apoptotic signalling exclusively. Instead, knockout of caspase-2 leads to tumor susceptibility in vivo, which led to the assumption, that caspase-2 has non-apoptotic functions and can act as a tumor suppressor.… Show more

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