Disruption of pupil size modulation correlates with voluntary motor preparation deficits in Parkinson's disease

Wang, Chin‐An; McInnis, Hailey; Brien, Donald C.; Pari, Giovanna; Munoz, Douglas P.

doi:10.1016/j.neuropsychologia.2015.11.019

Cited by 64 publications

(85 citation statements)

References 71 publications

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“…Pupillary abnormalities are thought to be associated with visual symptoms, especially blurred vision, and also correlate with other non‐motor and motor symptoms, including olfactory dysfunction, orthostatic heart rate change, cognitive impairment, and motor symptoms . In addition, pupillary abnormalities can present early in the disease course, even before motor symptoms occur .…”

Section: Abnormalities In Oculo‐visual Functionsmentioning

confidence: 99%

“…In addition, pupillary abnormalities can present early in the disease course, even before motor symptoms occur . Because modern pupillometry is a fast, objective, noninvasive, and low‐cost technique, this makes pupillary abnormalities an attractive prospect as potential nonmotor biomarkers for early detection and monitoring of disease progression in PD …”

Section: Abnormalities In Oculo‐visual Functionsmentioning

confidence: 99%

“…127,134 Pupillary abnormalities are thought to be associated with visual symptoms, especially blurred vision, 133 and also correlate with other non-motor and motor symptoms, including olfactory dysfunction, orthostatic heart rate change, cognitive impairment, and motor symptoms. [135][136][137][138][139] In addition, pupillary abnormalities can present early in the disease course, even before motor symptoms occur. 136,140 Because modern pupillometry is a fast, objective, noninvasive, and low-cost technique, this makes pupillary abnormalities an attractive prospect as potential nonmotor biomarkers for early detection and monitoring of disease progression in PD.…”

Section: Electrophysiologymentioning

confidence: 99%

“…136,140 Because modern pupillometry is a fast, objective, noninvasive, and low-cost technique, this makes pupillary abnormalities an attractive prospect as potential nonmotor biomarkers for early detection and monitoring of disease progression in PD. 128,133,136,138,139 Lens Cataract is common in PD patients in conjunction with other visual disturbances, yet few studies have addressed lens pathology. 141 In a retrospective cohort study, a 26% increased risk of cataract patients developing PD was found 142 ; vice versa, a significantly higher frequency of cataract was demonstrated in PD patients.…”

Section: Electrophysiologymentioning

confidence: 99%

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Oculo‐visual abnormalities in Parkinson's disease: Possible value as biomarkers

et al. 2018

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Parkinson's disease (PD) is one of the most common neurodegenerative disorders and the second leading cause of dementia worldwide. With an aging population, the prevalence of the disease has dramatically increased. Clinical management has advanced through recent developments in dopaminergic imaging and genetic risk profiling. However, early and accurate diagnosis of the disorder remains a challenge, largely because of the lack of noninvasive and inexpensive reliable diagnostic tests. Besides the well‐studied cerebral neurodegeneration that underlies the cardinal symptoms of PD (ie, bradykinesia, tremor, rigidity, and postural instability), ocular changes have also been described in PD, including visual dysfunction, pupil abnormality, lens opacity, and retinal neuronal loss and dysfunction. These ocular pathological processes are related to α‐synuclein deposition, and dopamine deficiency in the retina—mirroring the defining pathological features of PD in the brain. Together, these observations support the notion that the eye can serve as a window to the brain, providing clinicians with noninvasive methods to visualize disease. This review focuses on recent advances in the characterization of ocular changes in PD and their promising use as biomarkers in the eye, which can be potentially used for aiding in early diagnosis, tracking disease progression, and valuating novel therapeutic strategies. © 2018 International Parkinson and Movement Disorder Society

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Section: Abnormalities In Oculo‐visual Functionsmentioning

confidence: 99%

Section: Abnormalities In Oculo‐visual Functionsmentioning

confidence: 99%

Section: Electrophysiologymentioning

confidence: 99%

Section: Electrophysiologymentioning

confidence: 99%

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Oculo‐visual abnormalities in Parkinson's disease: Possible value as biomarkers

et al. 2018

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“…It may vary according to the interest a participant shows in a stimulus (Hess & Polt, 1960), their emotional state (Vanderhasselt, Remue, Ng, & De Raedt, 2014), the musical chill they experience (Laeng, Eidet, Sulutvedt, & Panksepp, 2016) and many other exciting concepts (Loewenfeld, 1999). This measure can even be a valid indicator for certain diseases, such as Parkinson's (Wang, McInnis, Brien, Pari, & Munoz, 2016). On the other hand, pupillometry is a rather coarse measure that often cannot provide specific predictions (failure in predicting sexual orientation: Savin- Williams, Cash, McCormack, & Rieger, 2016).…”

Section: Pupillometrymentioning

confidence: 99%

Unboxing the Black Box of Visual Expertise in Medicine

Jarodzka

Boshuizen

2017

FLR

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Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment

Opwonya,

Kim,

Lee

et al. 2024

Alz & Dem Diag Ass & Dis Mo

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INTRODUCTIONEye movement alterations are effective biomarkers for Alzheimer's disease (AD). This study examines task‐evoked pupillary responses (TEPRs) as potential biomarkers of the mild cognitive impairment (MCI), the symptomatic stage preceding AD.METHODSThe prospective cohort study included 213 MCI patients and 514 cognitively normal controls (CNs). Participants performed a prosaccade (PS) or antisaccade (AS) task while their eye movements were tracked using a Tobii Pro Spectrum system.RESULTSThe CNs showed unique TEPRs linked to better performance, characterized by larger baselines, greater PS target‐onset variability, and smaller AS target‐onset variability. Conversely, for MCI patients, better performance was linked to larger AS target‐onset sizes. Furthermore, MCI patients displayed reduced dilation during the cue and target‐onset periods compared to CNs.DISCUSSIONMCI patients showed altered pupillary response patterns associated with cognitive task performance, highlighting the potential of oculomotor changes as a biomarker for early cognitive decline.Highlights MCI patients displayed markedly smaller pupil dilation than CNs in response to cue and target stimuli. For MCI patients, larger pupil size upon target appearance during antisaccades correlated with better performance. Faster and more consistent prosaccades were linked to better performance in both groups. For MCI patients, the association between longer AS latencies and better performance was more pronounced than in CNs. Combined analysis of TEPRs and saccade performances in a sizeable cohort strengthens the generalizability of our findings to the broader MCI population.

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Disruption of pupil size modulation correlates with voluntary motor preparation deficits in Parkinson's disease

Cited by 64 publications

References 71 publications

Oculo‐visual abnormalities in Parkinson's disease: Possible value as biomarkers

Oculo‐visual abnormalities in Parkinson's disease: Possible value as biomarkers

Unboxing the Black Box of Visual Expertise in Medicine

Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment

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