Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved

Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice

“…Emerging studies have revealed that the pentose phosphate pathway is highly related to T2D and obesity as a vital part of glucose metabolism, and its flux is enhanced as glycolysis is activated and triggers the production of inflammatory factors to mobilize the inflammatory reaction ( Viola et al, 2019 ). Intriguingly, retinol metabolism also shows a close relationship with diabetes and obesity, especially in the state of diabetes and related diseases, and the dysfunction of the retinol metabolism cascade reveals that it may be a type of disease trigger ( Shin et al, 2020 ). These primary metabolic pathways, including the pentose phosphate pathway and retinol metabolism, showed 4 kinds of metabolites in total, especially with the relative abundance of gluconic acid, which showed fluctuation.…”

Combined Methylation and Transcriptome Analysis of Liver Injury of Nonalcoholic Fatty Liver Disease Induced by High Alcohol-Producing Klebsiella pneumoniae

“…The data of DNA methylation and transcriptome showed that the gene promoter region was hypomethylated, with upregulation of gene expression of Linp1 and RBP4 in EtOH-fed mice. Previous studies have shown that Linp1 is one of the key genes in adipogenesis ( 33 ), while RBP4 is elevated and associated with inflammation in metabolic diseases ( 34 ). However, our data showed that these genes were not significantly differentially expressed in the promoter region of W14-fed mice.…”

A Prognostic Model for In-Hospital Mortality in Critically Ill Patients with Pneumonia

“…RBP is an acute responsive protein, reflecting inflammation and nutritional determinants. 26 , 27 Recently, the serum RBP concentration was shown to be a crucial signal for the organ function, metabolism, and inflammation status of critically ill patients, especially the RBP4. 28 A low concentration of RBP at baseline was found associated with a bad outcome in liver ICU patients, which could predict short-term mortality of the patients, but not long-term mortality.…”