Disruption of spatial organization and interjoint coordination in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy

Leiguarda, R; Merello, Marcelo; Balej, Jorge; Starkstein, Sergio E.; Nogués, Martín; Marsden, C. D.

doi:10.1002/1531-8257(200007)15:4<627::aid-mds1006>3.0.co;2-5

Cited by 29 publications

(43 citation statements)

References 38 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This fits with previous observations of less well-formed gestures [10] and kinematic deficits [26] when PD patients pantomime actions. One possible explanation for this effect is an impairment of the mental representation underlying the gestures.…”

Section: Discussionsupporting

confidence: 92%

An investigation of co-speech gesture production during action description in Parkinson’s disease

Cleary

Poliakoff

Galpin

et al. 2011

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

a b s t r a c tIntroduction: Parkinson's disease (PD) can impact enormously on speech communication. One aspect of non-verbal behaviour closely tied to speech is co-speech gesture production. In healthy people, co-speech gestures can add significant meaning and emphasis to speech. There is, however, little research into how this important channel of communication is affected in PD. Methods: The present study provides a systematic analysis of co-speech gestures which spontaneously accompany the description of actions in a group of PD patients (N ¼ 23, Hoehn and Yahr Stage III or less) and age-matched healthy controls (N ¼ 22). The analysis considers different co-speech gesture types, using established classification schemes from the field of gesture research. The analysis focuses on the rate of these gestures as well as on their qualitative nature. In doing so, the analysis attempts to overcome several methodological shortcomings of research in this area. Results: Contrary to expectation, gesture rate was not significantly affected in our patient group, with relatively mild PD. This indicates that co-speech gestures could compensate for speech problems. However, while gesture rate seems unaffected, the qualitative precision of gestures representing actions was significantly reduced. Conclusions: This study demonstrates the feasibility of carrying out fine-grained, detailed analyses of gestures in PD and offers insights into an as yet neglected facet of communication in patients with PD. Based on the present findings, an important next step is the closer investigation of the qualitative changes in gesture (including different communicative situations) and an analysis of the heterogeneity in co-speech gesture production in PD.

show abstract

Section: Discussionsupporting

confidence: 92%

An investigation of co-speech gesture production during action description in Parkinson’s disease

Cleary

Poliakoff

Galpin

et al. 2011

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

show abstract

“…Leiguarda et al 1 provide an interesting description of the movement abnormalities in pantomiming a slicing bread action among patients with Parkinson's disease (PD), supranuclear palsy (PSP), or multisystem atrophy. These patients exhibit impairments in spatial precision of the movement trajectory, spatial temporal coupling, and interjoint coordination, and these impairments are seen to be greatest in the patients with PD and PSP who have ideomotor apraxia as measured on an apraxia screening test.…”

mentioning

confidence: 99%

“…These patients exhibit impairments in spatial precision of the movement trajectory, spatial temporal coupling, and interjoint coordination, and these impairments are seen to be greatest in the patients with PD and PSP who have ideomotor apraxia as measured on an apraxia screening test. Leiguarda et al 1 indicate that these impairments are the representation in kinematics of movement trajectory and external configuration errors observed in patients with PD and PSP patients who have ideomotor apraxia (IMA). Further support for the notion that these kinematic abnormalities are characteristic of apraxia, they argue, is seen in the similarity of these impairments to those observed in Poizner's studies of stroke patients with IMA.…”

mentioning

confidence: 99%

“…Further support for the notion that these kinematic abnormalities are characteristic of apraxia, they argue, is seen in the similarity of these impairments to those observed in Poizner's studies of stroke patients with IMA. [2][3][4] Leiguarda et al 1 then question whether these impairments relate to the basic movement deficits characteristic of basal ganglia diseases or to some higher-order deficit seen in IMA which appear similar to but less severe than the impairments observed in patients with stroke to the left cerebral hemisphere. They cite evidence that the basic deficit in hypokinesia in PD arises from defective cue production by the basal ganglia which leads to an impairment in preparing submovements performed in a sequence, particularly sequences that rely on memory and require limited attentional resources.…”

mentioning

confidence: 99%

“…Leiguarda et al 1 view the difference in a quantitative sense stating that "spatial abnormalities tended to be more severe in PD and PSP patients who exhibited praxic errors on clinical examination." They view these impairments as "the kinematic representation of the external configuration and movement (or trajectory) errors frequently found in Parkinson's disease and progressive supranuclear palsy patients with IMA."…”

mentioning

confidence: 99%

See 2 more Smart Citations

Apraxia in diseases of the basal ganglia

Roy

2000

Mov. Disord.

View full text Add to dashboard Cite

Lesions Responsible for Impaired Visual Perception in Poststroke Patients Using Voxel‐Based Lesion Symptom Mapping

et al. 2019

View full text Add to dashboard Cite

We aimed to clarify the clinical characteristics that affect visual perception (VP) and elucidate lesion locations correlated with impaired VP. We reviewed 61 patients with stroke. Clinical assessments of a motor‐free VP test were used to evaluate VP after stroke. Regression analyses were performed to examine predictors of impaired VP. We generated statistical maps of lesions related to impaired VP using voxel‐based lesion symptom mapping (VLSM). The group of patients who had right hemispheric lesions had significantly low VP function. In a regression model, impaired VP was predicted by cognitive function, age, lesion volume, and right hemispheric lesion. Using VLSM, we found lesion location associated with impaired VP after adjusting for age, lesion volume, and Korean version of mini mental status exam. The results showed a lesion pattern with predominant distribution in the right parietal lobe and deep white matter. Age, lesion volume, and cognitive impairment affected the results of VP tests. Even after adjustments, we found that lesions responsible for impaired VP were located in the right parietal lobe and deep white matter. This result confirmed right hemispheric dominance for VP using VLSM. Clin. Anat. 32:689–696, 2019. © 2019 Wiley Periodicals, Inc.

show abstract

Disruption of spatial organization and interjoint coordination in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy

Cited by 29 publications

References 38 publications

An investigation of co-speech gesture production during action description in Parkinson’s disease

An investigation of co-speech gesture production during action description in Parkinson’s disease

Apraxia in diseases of the basal ganglia

Lesions Responsible for Impaired Visual Perception in Poststroke Patients Using Voxel‐Based Lesion Symptom Mapping

Contact Info

Product

Resources

About