Disruption of the Body Temperature Circadian Rhythm in Hospitalized Patients

Geneva, Ivayla; Javaid, Waleed

doi:10.1016/j.amjms.2021.06.021

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…This is obvious because children experience more vigorous physiological metabolism and pregnant women undertake the metabolism of the fetus ( 35 , 36 ). Meanwhile, other factors affecting body temperature [ovulation cycle and circadian rhythm ( 37 , 38 ), for example] were not involved in this study. However, the method of fever screening should have universal applicability to meet the screening requirements in various situations.…”

Section: Discussionmentioning

confidence: 99%

Optimal diagnostic fever thresholds using non-contact infrared thermometers under COVID-19

Fan

Liu

et al. 2022

Front. Public Health

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Fever screening is an effective method to detect infectors associated with different variants of coronavirus disease 2019 (COVID-19) based on the fact that most infectors with COVID-19 have fever symptoms. Non-contact infrared thermometers (NCITs) are widely used in fever screening. Nevertheless, authoritative data is lacking in defining “fever” at different body surface sites when using NCITs. The purpose of this study was to determine the optimal diagnostic threshold for fever screening using NICTs at different body surface sites, to improve the accuracy of fever screening and provide theoretical reference for healthcare policy. Participants (n = 1860) who were outpatients or emergency patients at Chengdu Women's and Children's Central Hospital were recruited for this prospective investigation from March 1 to June 30, 2021. NCITs and mercury axillary thermometers were used to measure neck, temple, forehead and wrist temperatures of all participants. Receiver operating characteristic curves were used to reflect the accuracy of NCITs. Linear correlation analysis was used to show the effect of age on body temperature. Multilinear regression analysis was used to explore the association between non-febrile participant's covariates and neck temperature. The mean age of participants was 3.45 ± 2.85 years for children and 28.56 ± 7.25 years for adults. In addition 1,304 (70.1%) participants were children (≤12), and 683 (36.7%) were male. The neck temperature exhibited the highest accuracy among the four sites. Further the optimal fever diagnostic thresholds of NCITs at the four body surface measurement sites were neck (36.75 °C, sensitivity: 0.993, specificity: 0.858); temple (36.55 °C, sensitivity: 0.974, specificity: 0.874); forehead (36.45 °C, sensitivity: 0.961, specificity: 0.813); and wrist (36.15 °C, sensitivity: 0.951, specificity: 0.434). Based on the findings of our study, we recommend 36.15, 36.45, 36.55, and 36.75 °C as the diagnostic thresholds of fever at the wrist, forehead, temple and neck, respectively. Among the four surface sites, neck temperature exhibited the highest accuracy.

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Section: Discussionmentioning

confidence: 99%

Optimal diagnostic fever thresholds using non-contact infrared thermometers under COVID-19

Fan

Liu

et al. 2022

Front. Public Health

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“…The importance of the circadian rhythm has also been demonstrated in noncritically ill hospitalized patients. For instance, our group [79] found that among the 16,245 hospitalized patients included in the study, the circadian rhythm was disrupted Human Body Temperature Circadian Rhythm in Health and Disease DOI: http://dx.doi.org/10.5772/intechopen.1003852 in 80%. Further, we reported an age-dependent shift in the circadian pattern, with the body temperature bathyphase of older people shifted to 12 pm in the afternoon (compared with 8 am for young adults) but with the acrophase among the old remaining at 8 pm, similar to the younger patient cohort.…”

Section: Fever Hypothermia and Other Disruptions To The Human Body Te...mentioning

confidence: 99%

“…Further, we reported an age-dependent shift in the circadian pattern, with the body temperature bathyphase of older people shifted to 12 pm in the afternoon (compared with 8 am for young adults) but with the acrophase among the old remaining at 8 pm, similar to the younger patient cohort. (Figure 4, adopted with modifications and permission from Geneva et al [79]). After considering other theories, we had concluded that the most likely explanation for the circadian body temperature disruption during hospitalization was the disturbance in the patients' day-night light cycles caused by frequent awaking at night for procedures, vital signs measurements, and the associated exposure to light during the night.…”

Section: Fever Hypothermia and Other Disruptions To The Human Body Te...mentioning

confidence: 99%

Human Body Temperature Circadian Rhythm in Health and Disease

I. Geneva

2024

Heat Illness and Critical Care

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Human body temperature continues to be of interest to researchers with the newest discovery that it had been steadily decreasing since the mid-1800s, thus affecting our definition of normothermia and the cutoff for fever. Further, body temperature constitutes an explicit manifestation of our circadian rhythm, with temperature trough occurring in early morning and peak in the evening in healthy individuals. On the other hand, human illness, as seen among patients ranging from stable hospitalized ones to the critically ill, was shown to correlate with disturbance or even complete disappearance of the body temperature circadian rhythm. Also, night shift work affects the rhythm and had been associated with increased risk for malignancies, gastroenterological and metabolic disorders. Importantly, quantification of the observed rhythm deviations appears to have diagnostic and prognostic value in medicine. This chapter reviews the determinants of body temperature and the body temperature circadian rhythm, discusses the most prominent published research on associations between the rhythm and human disease, and concludes by outlining possible new research avenues and promising clinical applications in the field of chronotherapy.

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“…In a healthy human, the circadian rhythm influences major physiological functions, including the 24 h biological cycle of behavioural, physical, and mental changes. More specifically, the major physiology functions of circadian rhythm involve, among others, the sleep–wake cycle [ 12 , 13 ], blood pressure [ 14 , 15 ], body temperature [ 16 , 17 ], hormonal homeostasis [ 18 ], prothrombotic factor regulation [ 19 ], and hormone release in the digestive system to match eating habits [ 20 ]. Besides these, circadian rhythm is also important in the promotion of good metabolic balance, haemostasis, alertness or functional cognition, optimum cell repair, a healthy body, and healthy brain development, in addition to the boosting of the immune system [ 21 ].…”

Section: Human Circadian Rhythmmentioning

confidence: 99%

Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

et al. 2023

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The circadian system in the human body responds to daily environmental changes to optimise behaviour according to the biological clock and also influences various physiological processes. The suprachiasmatic nuclei are located in the anterior hypothalamus of the brain, and they synchronise to the 24 h light/dark cycle. Human physiological functions are highly dependent on the regulation of the internal circadian clock. Skeletal muscles comprise the largest collection of peripheral clocks in the human body. Both central and peripheral clocks regulate the interaction between the musculoskeletal system and energy metabolism. The skeletal muscle circadian clock plays a vital role in lipid and glucose metabolism. The pathogenesis of osteoporosis is related to an alteration in the circadian rhythm. In the present review, we discuss the disturbance of the circadian rhythm and its resultant effect on the musculoskeletal system. We also discuss the nutritional strategies that are potentially effective in maintaining the system’s homeostasis. Active collaborations between nutritionists and physiologists in the field of chronobiological and chrononutrition will further clarify these interactions. This review may be necessary for successful interventions in reducing morbidity and mortality resulting from musculoskeletal disturbances.

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Disruption of the Body Temperature Circadian Rhythm in Hospitalized Patients

Cited by 6 publications

References 25 publications

Optimal diagnostic fever thresholds using non-contact infrared thermometers under COVID-19

Optimal diagnostic fever thresholds using non-contact infrared thermometers under COVID-19

Human Body Temperature Circadian Rhythm in Health and Disease

Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

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