Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens

Touitou, Yvan; Bogdan, André; Lévi, Françis; Benavides, Manuel; Auzéby, A

doi:10.1038/bjc.1996.524

Cited by 126 publications

(77 citation statements)

References 9 publications

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“…Self-reported negative mood states have been associated with lower NK cell activity (Levy & Herberman, 1985;Levy et al 1991) and symptoms of depression have been linked with increased salivary cortisol (Ehlert et al 1990), impaired lymphocyte proliferation (Schleifer et al 1984;Maes, 1995) and reduced NK cell cytotoxicity against tumour cells (Nerozzi et al 1989;Caldwell et al 1991;Maes et al 1992). Studies have reported abnormal circadian rhythmicity of cortisol in breast cancer patients (Touitou et al 1996;van der Pompe et al 1996;Sephton et al 2000;Abercrombie et al 2004) and flattened or abnormal diurnal salivary cortisol rhythms have recently been associated with earlier mortality in breast cancer patients (Sephton et al 2000) and persistent fatigue in survivors 1 -5 years after initial diagnosis (Bower et al 2005).…”

Section: Other Potential Benefits Of Negative Energy Balance Intervenmentioning

confidence: 99%

Diet, physical activity and energy balance and their impact on breast and prostate cancers

Saxton

2006

Nutr. Res. Rev.

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Obesity, physical activity status and circulating levels of sex steroid hormones and growth factor proteins are intrinsically linked to energy balance. Epidemiological studies have previously reported associations between these factors and the risk of hormone-related cancers such as prostate and breast cancer in men and postmenopausal women. An increasing number of intervention studies in 'at-risk' populations and cancer survivors are now investigating the effects of lifestyle interventions that promote negative energy balance on circulating levels of sex hormones and growth factor proteins as surrogate markers of cancer risk. Evidence from these studies suggests that lifestyle interventions can improve insulin sensitivity, alter the balance of circulating sex steroid hormones and insulin-like growth factor (IGF) axis proteins (including IGF-1 and the IGF binding proteins 1 and 3) and change the functioning of immune cells in peripheral blood. Such changes could influence the risk of developing hormone-related cancers, as well as having the potential to improve disease-free survival in patients recovering from cancer treatment. However, despite promising results, the methodological quality of most intervention studies has been limited due to small subject numbers, lack of adequate control groups or nonrandomised designs and the absence of long-term follow-up measures. More intervention studies with randomised controlled designs, higher numbers of subjects and longer-term follow-up measures are needed to establish which combination of specific dietary and physical activity interventions work best for reducing risk in 'at-risk' populations and survivors, optimal doseresponse relationships and the magnitude of change in surrogate markers of cancer risk that is required to induce a protective effect.

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Section: Other Potential Benefits Of Negative Energy Balance Intervenmentioning

confidence: 99%

Diet, physical activity and energy balance and their impact on breast and prostate cancers

Saxton

2006

Nutr. Res. Rev.

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“…Diurnal changes in cortisol are known to change the number and function of immune cells, which could affect the suppression of proinflammatory cytokine production [80,97]. In addition, flattened cortisol rhythms in patients with breast cancer have been shown to be associated with altered immune function [89,98].…”

Section: Thementioning

confidence: 99%

“…These include changes in endocrine rhythms (e.g., cortisol, melatonin, and prolactin secretion), metabolic processes (e.g., temperature and circulating protein levels), the immune system (e.g., levels of circulating leukocytes and neutrophils), and rest-activity patterns [73,[82][83][84][85][86][87][88][89]. Types of rhythm alteration include diminished amplitude, phase shifts, period changes, and erratic peaks and troughs.…”

Section: Thementioning

confidence: 99%

Mechanisms of Cancer-Related Fatigue

Ryan¹,

Carroll²,

Ryan³

et al. 2007

The Oncologist

494

408

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Cancer-related fatigue (CRF) is one of the most prevalent symptoms patients with cancer experience, both during and after treatment. CRF is pervasive and affects patients' quality of life considerably. It is important, therefore, to understand the underlying pathophysiology of CRF in order to develop useful strategies for prevention and treatment. At present, the etiology of CRF is poorly understood and the relative contributions of the neoplastic disease, various forms of cancer therapy, and comorbid conditions (e.g., anemia, cachexia, sleep disorders, depression) remain unclear. In any individual, the etiology of CRF probably involves the dysregulation of several physiological and biochemical systems. Mechanisms proposed as underlying CRF include 5-HT neurotransmitter dysregulation, vagal afferent activation, alterations in muscle and ATP metabolism, hypothalamic-pituitary-adrenal axis dysfunction, circadian rhythm disruption, and cytokine dysregulation. Currently, these hypotheses are largely based on evidence from other conditions in which fatigue is a characteristic, in particular chronic fatigue syndrome and exercise-induced fatigue. The mechanisms that lead to fatigue in these conditions provide a theoretical basis for future research into the complex etiology of this distressing and debilitating symptom. An understanding of relevant mechanisms may offer potential routes for its prevention and treatment in patients with cancer.

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“…Several stud-ies have shown blunted or altered circadian rhythms of different physiological variables [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

A Multicentric Study of Long:term Rhythm Patterns in Heart Rate

Goya–Esteban

Barquero-Pérez

Alzueta

et al. 2016

2016 Computing in Cardiology Conference (CinC)

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Heart rate (HR) shows oscillations with different periods as a result of the sympatho-vagal balance. The most studied ones are short-period variations and the circadian pattern. However, the existence of rhythms of longer periods has not been systematically studied.The aim of this work is to study HR long-period rhythms in a multicentric database including 336 patients in sinus rhythm, with implanted cardioverter defibrillator. We used two methodological approaches: First a rhythmometric procedure to automatically select the statistically significant rhythms present in the signal; Second, the LASSO path approach to analyze the order of activation of the rhythms, representing the importance of each rhythm.Most of the population showed a significant annual rhythm (78% day/80% night). Weekly and quarterly rhythms were also present (weekly 26% /26% ; quarterly 22%/21%). Monthly rhythm was rarely present. Most present rhythm combinations were annual plus weekly (21%/21%) and annual plus quarterly (19%/18%). The order of activation given by the LASSO path was in agreement with the multicomponent rhythmometric model in the 86%/85% of the cases.The unusual long monitoring period, and the high number of patients, represent an ideal scenario to robustly assess the existence of long-term rhythms.

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Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens

Cited by 126 publications

References 9 publications

Diet, physical activity and energy balance and their impact on breast and prostate cancers

Diet, physical activity and energy balance and their impact on breast and prostate cancers

Mechanisms of Cancer-Related Fatigue

A Multicentric Study of Long:term Rhythm Patterns in Heart Rate

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