Disruption of the early-life microbiota alters Peyer’s patch development and germinal center formation in gastrointestinal-associated lymphoid tissue

Borbet, Timothy C.; Pawline, Miranda B.; Li, Jackie; Ho, Melody; Yin, Yue; Zhang, Xiaozhou; Novikova, Ekaterina V.; Jackson, Katelyn; Mullins, Briana J.; Ruiz, Victoria E.; Hines, Marcus J.; Müller, Anne; Koralov, Sergei B.

doi:10.1016/j.isci.2023.106810

Cited by 9 publications

(3 citation statements)

References 71 publications

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“…Early gut colonization has been shown to have long-lasting consequences. These consequences are related to an increased risk of developing malnutrition and metabolic or immunological disease in late life [ 27 ]. The intestinal microbiota is known to influence the development and balance of the host immune system.…”

Section: Discussionmentioning

confidence: 99%

Influence of feeding practices in the composition and functionality of infant gut microbiota and its relationship with health

Martínez-Martínez,

Soria-Guerra

et al. 2024

PLoS ONE

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Establishing the infant’s gut microbiota has long-term implications on health and immunity. Breastfeeding is recognized as the best practice of infant nutrition in comparison with formula feeding. We evaluated the effects of the primary feeding practices by analyzing the infant growth and the potential association with gut diseases. A cross-sectional and observational study was designed. This study included 55 mothers with infants, who were divided according to their feeding practices in breastfeeding (BF), formula feeding (FF), and combined breast and formula feeding (CF). Anthropometric measurements of the participants were recorded. Additionally, non-invasive fecal samples from the infants were collected to analyze the microbiota by sequencing, immunoglobulin A (IgA) concentration (ELISA), and volatile organic compounds (gas chromatography with an electronic nose). Results showed that the microbiota diversity in the BF group was the highest compared to the other two groups. The IgA levels in the BF group were twice as high as those in the FF group. Moreover, the child´s growth in the BF group showed the best infant development when the data were compared at birth to the recollection time, as noted by the correlation with a decreased concentration of toxic volatile organic compounds. Interestingly, the CF group showed a significant difference in health status when the data were compared with the FF group. We conclude that early health practices influence children’s growth, which is relevant to further research about how those infants’ health evolved.

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Section: Discussionmentioning

confidence: 99%

Influence of feeding practices in the composition and functionality of infant gut microbiota and its relationship with health

Martínez-Martínez,

Soria-Guerra

et al. 2024

PLoS ONE

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“… 170 , 171 The disruption of the microbial community in the early stages of life has been found to alter the development of PP within the GALT and the formation of germinal centers, while fewer IELs, Tregs and SIgA were presented in germ-free mice. 172 , 173 The stimulation of LPLs by Lactobacillus can induce the secretion of IL-22 and activate the STAT3 signaling pathway, thereby promoting the regeneration of ISCs and facilitating the renewal and repairment of IECs. 174 Additionally, the gut microbiota exerts an influence on the levels of conjugated linoleic acid within the mouse intestine, thereby augmenting the population of intraepithelial lymphocytes through a mechanism associated with the activation of transcription factors HNF4γ and ThPOK.…”

Section: Gut Microbiota and Intestinal Mucosal Immune Barriermentioning

confidence: 99%

“…The commensal bacteria in gut and their derived metabolites could modulate the intestinal immune microenvironment and the development or maturation of a variety of immune cells, resulting in the enhancement of intestinal mucosal immunity 170,171. The disruption of the microbial community in the early stages of life has been found to alter the development of PP within the GALT and the formation of germinal centers, while fewer IELs, Tregs and SIgA were presented in germ-free mice 172,173. The stimulation of LPLs by Lactobacillus can induce the secretion of IL-22 and activate the STAT3 signaling pathway, thereby promoting the regeneration of ISCs and facilitating the renewal and repairment of IECs 174.…”

mentioning

confidence: 99%

Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis

Li,

Wang,

Cao

et al. 2024

JIR

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The pathogenesis of severe acute pancreatitis-associated acute lung injury (SAP-ALI), which is the leading cause of mortality among hospitalized patients in the intensive care unit, remains incompletely elucidated. The intestinal mucosal immune barrier is a crucial component of the intestinal epithelial barrier, and its aberrant activation contributes to the induction of sustained pro-inflammatory immune responses, paradoxical intercellular communication, and bacterial translocation. In this review, we firstly provide a comprehensive overview of the composition of the intestinal mucosal immune barrier and its pivotal roles in the pathogenesis of SAP-ALI. Secondly, the mechanisms of its crosstalk with gut microbiota, which is called gut-lung axis, and its effect on SAP-ALI were summarized. Finally, a number of drugs that could enhance the intestinal mucosal immune barrier and exhibit potential anti-SAP-ALI activities were presented, including probiotics, glutamine, enteral nutrition, and traditional Chinese medicine (TCM). The aim is to offer a theoretical framework based on the perspective of the intestinal mucosal immune barrier to protect against SAP-ALI.

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Gut microbiota and immunity in health and diseases: a review

Okolie,

Edo,

Ainyanbhor

et al. 2024

Proc.Indian Natl. Sci. Acad.

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Disruption of the early-life microbiota alters Peyer’s patch development and germinal center formation in gastrointestinal-associated lymphoid tissue

Cited by 9 publications

References 71 publications

Influence of feeding practices in the composition and functionality of infant gut microbiota and its relationship with health

Influence of feeding practices in the composition and functionality of infant gut microbiota and its relationship with health

Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis

Gut microbiota and immunity in health and diseases: a review

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