Disruption of Tissue Mast Cells in Mice

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

“…Mota (50) reported that mice or rats dying ofanaphylaxis after passive sensitization did not exhibit significant mast cell degranulation; and Lima et al (51) reported that little mast cell degranulation occurred in mice dying of reverse passive anaphylaxis. Similarly, mice (51) or rats (50) exhibiting severe or fatal anaphylaxis due to injection of soluble antigen-antibody complexes exhibited little or no mast cell degranulation.…”

Mast Cell Disruption in Heterophile Anaphylaxis of the Mouse

“…Mast cell damage in isophile anaphylaxis of the mouse has been described in several reports (1)(2)(3)(4)(5). The only reference dealing with experiments on the role of mast cells in heterophile anaphylaxis is that of H umphrey and M ota (6).…”