Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness

Mäki-Marttunen, Verónica; Diez, Ibai; Cortes, Jesús M.; Chialvo, Dante R.; Villarreal, Mirta F.

doi:10.3389/fninf.2013.00024

Cited by 55 publications

(43 citation statements)

References 35 publications

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“…23 Interhemispheric connectivity was reduced when seeds were set in the precentral gyrus, postcentral gyrus and intraparietal sulcus, or across the brain. 22,28 In a study in which seeds were placed in the thalamus, patients in VS demonstrated a greater reduction in connectivity of the nonspecific thalamic connections of the intralaminar nuclei associated with the ascending reticular activating system than in the specific thalamic connections related to the thalamic sensory and motor relay functions. 34 Brain network topology was assessed through graph theoretical approaches in several studies.…”

Section: Systematic Review Population Characteristicsmentioning

confidence: 99%

“…40 Other neuronal systems in which decreased functional connectivity was noted in patients with DOC included left and right executive control, auditory, and attention networks. 18,21 Six studies evaluated functional connectivity using seedbased correlative analysis [22][23][24]28,34,40 (table e-3). Intrinsic connectivity of the DMN was found to be decreased in patients with MCS and VS, 23,40 while extrinsic connectivity between DMN and limbic structures was increased.…”

Section: Systematic Review Population Characteristicsmentioning

confidence: 99%

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Resting brain activity in disorders of consciousness

et al. 2015

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Objective: To quantitatively synthesize results from neuroimaging studies that evaluated patterns of resting functional activity in patients with disorders of consciousness (DOC).Methods: We performed a systematic review and coordinate-based meta-analysis of studies published up to May 2014. Studies were included if they compared resting-state functional neuroimaging data acquired in patients with DOC (coma, minimally conscious state, emergence from minimally conscious state, or vegetative state) with a group of healthy controls. Coordinate-based meta-analysis was performed in studies that included voxel-based comparisons at the whole-brain level and if analysis was accomplished with data-driven approaches.Results: A total of 36 studies (687 patients, 637 healthy controls) were included in the systematic review. Reported DOC were vegetative state (43.2%), coma (23.4%), minimally conscious state (22.8%), and emergence from minimally conscious state (1.6%); the most common etiologies of DOC were traumatic brain injury (37.7%) and anoxic brain injury (36.9%). Functional neuroimaging was accomplished using fMRI (16 studies), PET (15 studies), SPECT (4 studies), and both PET and SPECT in one study. Meta-analysis in 13 studies (272 patients, 259 healthy controls) revealed consistently reduced activity in patients with DOC in bilateral medial dorsal nucleus of the thalamus, left cingulate, posterior cingulate, precuneus, and middle frontal and medial temporal gyri. Conclusions:In patients with DOC evaluated in the resting state, functional neuroimaging indicates markedly reduced activity within midline cortical and subcortical sites, anatomical structures that have been linked to the default-mode network. Studies are needed to determine the relation between activation (and coherence) within these structures and the emergence of conscious awareness. Neurology ® 2015;84:1272-1280 GLOSSARY ALE 5 activation likelihood estimate; ALFF 5 amplitude of low-frequency fluctuations; BOLD 5 blood oxygen level-dependent; CRS-R 5 Coma Recovery Scale-Revised; DMN 5 default mode network; DOC 5 disorders of consciousness; EMCS 5 emergence from minimally conscious state; FDG 5 fluorodeoxyglucose; HC 5 healthy control; ICA 5 independent component analysis; MCS 5 minimally conscious state; MNI 5 Montreal Neurological Institute; PCC 5 posterior cingulate cortex; ReHo 5 regional homogeneity; ROI 5 region of interest; TBI 5 traumatic brain injury; VS 5 vegetative state.Coma is a cardinal sign of brain injury resulting from trauma, stroke, cardiac arrest, infection, or metabolic causes. While coma is a transient state from which the majority of subjects awaken, a subset of patients develop a more prolonged impairment in consciousness, such as the vegetative state (VS) or minimally conscious state (MCS). Despite considerable research, states such as coma, VS, and MCS-collectively termed disorders of consciousness (DOC)-remain poorly understood regarding their neural basis, clinical recognition, and long-term outcome.1,2 Neurophysiologic...

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Section: Systematic Review Population Characteristicsmentioning

confidence: 99%

Section: Systematic Review Population Characteristicsmentioning

confidence: 99%

Resting brain activity in disorders of consciousness

et al. 2015

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“…We applied resting fMRI preprocessing similar to previous work (Alonso-Montes et al, 2015;Amor et al, 2015;Diez, Erramuzpe, et al, 2015;Diez, Bonifazi, et al, 2015;Diez et al, 2017;Mäki-Marttunen, Diez, Cortes, Chialvo, & Villarreal, 2013;Marinazzo et al, 2014;Rasero, Pellicoro, et al, 2017;Stramaglia et al, 2016Stramaglia et al, , 2017Stramaglia, Angelini, Cortes, & Marinazzo, 2015) using FSL and AFNI (http://afni.nimh.nih.gov/afni/). First, slice-time correction was applied to the fMRI data set.…”

Section: Functional Mrimentioning

confidence: 99%

Structure–function multi‐scale connectomics reveals a major role of the fronto‐striato‐thalamic circuit in brain aging

Bonifazi

Erramuzpe

Diez

et al. 2018

Human Brain Mapping

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Physiological aging affects brain structure and function impacting morphology, connectivity, and performance. However, whether some brain connectivity metrics might reflect the age of an individual is still unclear. Here, we collected brain images from healthy participants (N = 155) ranging from 10 to 80 years to build functional (resting state) and structural (tractography) connectivity matrices, both data sets combined to obtain different connectivity features. We then calculated the brain connectome age—an age estimator resulting from a multi‐scale methodology applied to the structure–function connectome, and compared it to the chronological age (ChA). Our results were twofold. First, we found that aging widely affects the connectivity of multiple structures, such as anterior cingulate and medial prefrontal cortices, basal ganglia, thalamus, insula, cingulum, hippocampus, parahippocampus, occipital cortex, fusiform, precuneus, and temporal pole. Second, we found that the connectivity between basal ganglia and thalamus to frontal areas, also known as the fronto‐striato‐thalamic (FST) circuit, makes the major contribution to age estimation. In conclusion, our results highlight the key role played by the FST circuit in the process of healthy aging. Notably, the same methodology can be generally applied to identify the structural–functional connectivity patterns correlating to other biomarkers than ChA.

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“…Unusual material properties-such as superconductivity, metal-insulator transitions, and heavy fermions-have been attributed to collective behavior arising from the compounded interaction of system components [1]. Collective behavior is by no means limited to complex materials, however: the behavior of financial markets [2], epileptic seizures [3] and consciousness [4], and animal flocking behavior [5] are all also seen as examples. We now appreciate that it appears most prominently via phase transitions ( [6] and references therein).…”

Section: Introductionmentioning

confidence: 99%

Anatomy of a Spin: The Information-Theoretic Structure of Classical Spin Systems

Vijayaraghavan

James

Crutchfield

2017

Entropy

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Collective organization in matter plays a significant role in its expressed physical properties. Typically, it is detected via an order parameter, appropriately defined for each given system's observed emergent patterns. Recent developments in information theory, however, suggest quantifying collective organization in a system-and phenomenon-agnostic way: decomposing the system's thermodynamic entropy density into a localized entropy, that is solely contained in the dynamics at a single location, and a bound entropy, that is stored in space as domains, clusters, excitations, or other emergent structures. As a concrete demonstration, we compute this decomposition and related quantities explicitly for the nearest-neighbor Ising model on the 1D chain, on the Bethe lattice with coordination number k = 3, and on the 2D square lattice, illustrating its generality and the functional insights it gives near and away from phase transitions. In particular, we consider the roles that different spin motifs play (in cluster bulk, cluster edges, and the like) and how these affect the dependencies between spins.

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Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness

Cited by 55 publications

References 35 publications

Resting brain activity in disorders of consciousness

Resting brain activity in disorders of consciousness

Structure–function multi‐scale connectomics reveals a major role of the fronto‐striato‐thalamic circuit in brain aging

Anatomy of a Spin: The Information-Theoretic Structure of Classical Spin Systems

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