Disruptions within gut microbiota composition induced by improper antibiotics therapy as a probable trigger factor for development of depression – Case Reports

Janowska, Małgorzata; Róg, Joanna; Karakuła-Juchnowicz, Hanna

doi:10.26444/aaem/132452

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…This would be a variation of the “hygiene hypothesis” [ 28 , 29 , 32 ]. A third possibility is that enteric infections could lead patients to receive treatment with antibiotics, which could alter the gut microbiome and trigger depressive or manic episodes [ 51 , 52 , 158 , 159 ]. The current results highlight the need to examine the links between enteric infections, gut microbiota, inflammation, and alterations in brain functioning in patients with mood disorders.…”

Section: Discussionmentioning

confidence: 99%

Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990–2019

Rajkumar

2023

Diseases

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Mood disorders are among the commonest mental disorders worldwide. Epidemiological and clinical evidence suggests that there are close links between infectious diseases and mood disorders, but the strength and direction of these association remain largely unknown. Theoretical models have attempted to explain this link based on evolutionary or immune-related factors, but these have not been empirically verified. The current study examined cross-sectional and longitudinal associations between the incidence of infectious diseases and mood disorders, while correcting for climate and economic factors, based on data from the Global Burden of Disease Studies, 1990–2019. It was found that major depressive disorder was positively associated with lower respiratory infections, while bipolar disorder was positively associated with upper respiratory infections and negatively associated with enteric and tropical infections, both cross-sectionally and over a period of 30 years. These results suggest that a complex, bidirectional relationship exists between these disorders. This relationship may be mediated through the immune system as well as through the gut–brain and lung–brain axes. Understanding the mechanisms that link these groups of disorders could lead to advances in the prevention and treatment of both.

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Section: Discussionmentioning

confidence: 99%

Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990–2019

Rajkumar

2023

Diseases

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“…Together, these changes may affect long term microbiome research, both in observational as well as in population studies, requiring urgent attention. Increasing preclinical and clinical studies have highlighted that compositional and functional (e.g., metabolite) changes in gut microbiota, known as dysbiosis, are associated with the onset and progression of depression via regulating the gut-brain axis [63][64][65]. Thus, it can be assumed that the results may have been influenced by the above factors, which occurred as a post-COVID-syndrome.…”

Section: Aaem Annals Of Agricultural and Environmental Medicinementioning

confidence: 99%

Intensification of anxiety, symptoms of depression, and level of social support among women in pathological pregnancy – a cross-sectional preliminary study

Makara - Studzińska,

Zaręba,

Wdowiak

et al. 2024

Ann Agric Environ Med.

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“…Due to the impaired functioning of the intestinal barrier, bacteria migrate from the gastrointestinal tract, which activates the cells of the immune system and affects the functioning of the immune, endocrine, and nervous systems [80][81][82]. Certain factors negatively affect the functioning and selectivity of the intestinal barrier, including increased concentrations of IL-1β, IL-6, TNF-α, IFN-γ, and NF-κB, increased production of ROS and nitric oxide (NO), and decreased concentrations of exogenous antioxidants [83].…”

Section: Microbiota and Systemic Inflammation In Depressionmentioning

confidence: 99%

Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols—Polyphenols as an Element of Diet Therapy in Depressive Disorders

Winiarska-Mieczan

Kwiecień

Jachimowicz

et al. 2023

IJMS

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Depressive disorders can affect up to 350 million people worldwide, and in developed countries, the percentage of patients with depressive disorders may be as high as 10%. During depression, activation of pro-inflammatory pathways, mitochondrial dysfunction, increased markers of oxidative stress, and a reduction in the antioxidant effectiveness of the body are observed. It is estimated that approximately 30% of depressed patients do not respond to traditional pharmacological treatments. However, more and more attention is being paid to the influence of active ingredients in food on the course and risk of neurological disorders, including depression. The possibility of using foods containing polyphenols as an element of diet therapy in depression was analyzed in the review. The possibility of whether the consumption of products such as polyphenols could alleviate the course of depression or prevent the progression of it was also considered. Results from preclinical studies demonstrate the potential of phenolic compounds have the potential to reduce depressive behaviors by regulating factors related to oxidative stress, neuroinflammation, and modulation of the intestinal microbiota.

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Disruptions within gut microbiota composition induced by improper antibiotics therapy as a probable trigger factor for development of depression – Case Reports

Abstract: Disruptions within gut microbiota composition induced by improper antibiotics therapy as a probable trigger factor for development of depression -Case Reports. Ann Agric Environ Med.

Cited by 6 publications

References 45 publications

Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990–2019

Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990–2019

Intensification of anxiety, symptoms of depression, and level of social support among women in pathological pregnancy – a cross-sectional preliminary study

Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols—Polyphenols as an Element of Diet Therapy in Depressive Disorders

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