Disruptive effects of prefeeding and haloperidol administration on multiple measures of food-maintained behavior in rats

Hayashi, Yusuke; Wirth, Oliver

doi:10.1016/j.beproc.2011.12.011

Cited by 1 publication

(1 citation statement)

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“…Hunger state can alter the effectiveness of food reinforcement (Hayashi and Wirth 2012; Murphy et al 2003) and drug reinforcement (Carroll and Meisch 1984; Kerstetter et al 2012). Furthermore, palatable food can affect endogenous opioid signaling, and opioid drugs can affect feeding (Gosnell and Levine 2009).…”

Section: Discussionmentioning

confidence: 99%

Choice between delayed food and immediate oxycodone in rats

et al. 2016

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Rationale The choice to seek immediate drug effects instead of more meaningful but delayed rewards is a defining feature of addiction. Objectives To develop a rodent model of this behavior, we allowed rats to choose between immediate intravenous delivery of the prescription opioid oxycodone (50 μg/kg) and delayed delivery of palatable food pellets. Results Rats preferred food at delays up to 30 s, but they chose oxycodone and food equally at 60-s delay and preferred oxycodone over food at 120-s delay. Comparison of food-drug choice, food-only, and drug-only conditions indicated that food availability decreased drug intake, but drug availability increased food intake. In the food-only condition, food was effective as a reinforcer even when delayed by 120 s. Pre-session feeding with chow slowed acquisition of food and drug self-administration, but did not affect choice. To establish procedures for testing potential anti-addiction medications, noncontingent pretreatment with oxycodone or naltrexone (analogous to substitution and antagonist therapies, respectively) were tested on a baseline in which oxycodone was preferred over delayed food. Naltrexone pretreatment decreased drug intake and increased food intake. Oxycodone pretreatment decreased drug intake, but also produced extended periods with no food or drug responding. Conclusions These findings show that the contingencies that induce preference for drugs over more meaningful but less immediate rewards in humans can be modeled in rodents, and they suggest that the model could be useful for assessing the therapeutic potential of treatments and exploring the underlying behavioral and neural mechanisms involved in addiction.

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