Dissecting and Tracing the Gut Microbiota of Infants with Botulism: A Cross Sectional and Longitudinal Study

Wang, Dai; Li, Kexin; Wang, Limin; Zhang, Teng; Luo, Xin; Sun, Hui; Huang, Ying; Hu, Songnian; Lan, Ruiting; Xu, Xuefang; He, Zilong; Xu, Jianguo

doi:10.2139/ssrn.4508418

Cited by 1 publication

(2 citation statements)

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“…Several isolates showed 0 SNPs by PD's SNP calling methods, including soil isolate PDT001611442.1 and clinical isolate PDT001611423.1 from the Beijing area (Figure 3, Supplemental Data File 2). The studies identified a dominance of ST31 and ST32 C. botulinum strains colonizing infected infants 85 , and new associations with soil isolates identified from regional sampling.…”

Section: Botulinum Genomic Clusters Shared Among Foodborne Environmen...mentioning

confidence: 86%

“…A longitudinal cohort of infant botulism type B cases and soil samples were reported in PD by the Chinese Center for Disease and Prevention from Northern China 85 . A total of 22 isolates in cluster PDS000136320.1 (Supplemental Data File 2) demonstrated an average of 25 SNPs with a range of 0-38 SNPs among isolates.…”

Section: Botulinum Genomic Clusters Shared Among Foodborne Environmen...mentioning

confidence: 99%

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Approaching pathogenicClostridiafrom a One Health perspective

Cersosimo,

Worley,

Bry

2024

Preprint

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Spore-forming pathogens have a unique capacity to thrive in diverse environments, and with temporal persistence afforded through their ability to sporulate. These behaviors require a One Health approach to identify critical reservoirs and outbreak-associated transmission chains, given their capacity to freely move across soils, waterways, foodstuffs, and as commensals or infecting pathogens in human and veterinary populations. Among anaerobic spore-formers, genomic resources for pathogens includingC.botulinum,C.difficile, andC.perfringensenable our capacity to identify common and unique factors that support their persistence in diverse reservoirs and capacity to cause disease. Publicly available genomic resources for spore-forming pathogens at NCBI’s Pathogen Detection program aid outbreak investigations and longitudinal monitoring in national and international programs in public health and food safety, as well as for local healthcare systems. These tools also enable research to derive new knowledge regarding disease pathogenesis, and to inform strategies in disease prevention and treatment. As global community resources, the continued sharing of strain genomic data and phenotypes further enhances international resources and means to develop impactful applications. We present examples showing use of these resources in surveillance, including capacity to assess linkages among clinical, environmental, and foodborne reservoirs and to further research investigations into factors promoting their persistence and virulence in different settings.

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Section: Botulinum Genomic Clusters Shared Among Foodborne Environmen...mentioning

confidence: 86%

Section: Botulinum Genomic Clusters Shared Among Foodborne Environmen...mentioning

confidence: 99%